The Ins and Outs of miRNA-Mediated Gene Silencing during Neuronal Synaptic Plasticity

Dipen Rajgor, Jonathan Hanley

Research output: Contribution to journalArticle (Academic Journal)peer-review

4 Citations (Scopus)
267 Downloads (Pure)

Abstract

Neuronal connections through specialized junctions, known as synapses, create circuits that underlie brain function. Synaptic plasticity, i.e., structural and functional changes to synapses, occurs in response to neuronal activity and is a critical regulator of various nervous system functions, including long-term memory formation. The discovery of mRNAs, miRNAs, ncRNAs, ribosomes, translational repressors, and other RNA binding proteins in dendritic spines allows individual synapses to alter their synaptic strength rapidly through regulation of local protein synthesis in response to different physiological stimuli. In this review, we discuss our understanding of a number of miRNAs, ncRNAs, and RNA binding proteins that are emerging as important regulators of synaptic plasticity, which play a critical role in memory, learning, and diseases that arise when neuronal circuits are impaired
Original languageEnglish
JournalNon-Coding RNA
Volume2
Issue number1
Early online date11 Jan 2016
DOIs
Publication statusPublished - Mar 2016

Keywords

  • Synaptic plasticity
  • Synopase
  • miRNAs
  • ncRNAs
  • RNA binding proteins

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