The insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women

I Dos Santos Silva, N Johnson, B De Stavola, G Torres-Mejia, O Fletcher, DS Allen, NE Allen, TJ Key, IS Fentiman, JMP Holly, J Peto

Research output: Contribution to journalArticle (Academic Journal)peer-review

53 Citations (Scopus)

Abstract

High levels of circulating insulin-like growth factor-I (IGF-I) and its major binding protein (IGFBP-3) at premenopausal ages have been associated with an increased breast cancer risk. We conducted a cross-sectional study (215 premenopausal women and 241 after natural menopause) nested within the Guernsey prospective studies to examine the relationship between the IGF system and mammographic features of the breast. The mammographically dense area in the breast increased with increasing serum levels of IGF-I (P for linear trend, Pt = 0.05), IGF-II (Pt = 0.08), and IGFBP-3 (Pt = 0.01) only in premenopausal women. IGF-II and IGFBP-3 serum levels were associated with increases in the mammographically lucent area in both premenopausal (Pt = 0.01 and 0.04, respectively) and postmenopausal women (Pt <0.001 for both), but these associations were no longer statistically significant after adjustment for body mass index and waist circumference. Neither the IGF-I/IGFBP-3 nor the IGF-II/IGFBP-3 molar ratio was associated with any of these mammographic features. The number of A alleles at a polymorphic locus in the promoter region of the IGFBP-3 gene was associated with increasing mean IGFBP-3 levels in both premenopausal (Pt = 0.01) and postmenopausal (Pt
Translated title of the contributionThe insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women
Original languageEnglish
Pages (from-to)449 - 455
Number of pages7
JournalCancer Epidemiology, Biomarkers and Prevention
Volume15 (3)
DOIs
Publication statusPublished - Mar 2006

Bibliographical note

Publisher: American Association for Cancer Research

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