The Investigation and Management of Iliac Artery Endofibrosis: Lessons Learned from a Case Series

Lewis K. Peake, Fabrizio D'Abate, John Farrah, Maria Morgan, Robert J. Hinchliffe*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)
236 Downloads (Pure)


Objective/background: The objective was to summarise the lessons learned, and evolution in local practice over the last 7 years, in the investigation and surgical management of iliac artery endofibrosis. Methods: This was a retrospective case series. A case note review of consecutive patients investigated for suspected iliac artery endofibrosis by a single surgeon, over a 7 year period, was undertaken. Included were cases of first presentation and those who had previously undergone intervention. Results: Some 63 patients were referred with suspected endofibrosis in the period 2011–17, four of whom had previously undergone surgery for the condition. After investigation of both limbs, 50 symptomatic limbs in 46 patients had a confirmed diagnosis; amongst those 46 patients, iliac artery endofibrosis was found in a further six asymptomatic, contralateral limbs. Individuals were diagnosed at a median age of 36 years (range 18–52 years) and typically presented with thigh claudication, foot numbness, and limb weakness on exercise. The median delay to diagnosis was 3 years (range 0–14 years). Complete external iliac artery occlusion was a feature in three cases. Overall, 27 limbs in 25 patients underwent operative repair; a further five limbs in four patients underwent operative repair at other centres internationally. There were three post-operative superficial wound infections (11%) and one below knee deep vein thrombosis (4%). Symptoms resolved in 23 cases (85%) with a median follow up of 2.1 years (range 65 days–5.7 years). Of the four limbs developing recurrent symptoms, two had undergone surgery for an occluded external iliac artery. Conclusion: Surgical repair in the medium term appears effective in resolving symptoms in most patients. Further investigation is needed to establish the durability of surgery and to delineate the natural history of the disease.

Original languageEnglish
Pages (from-to)577-583
Number of pages7
JournalEuropean Journal of Vascular and Endovascular Surgery
Issue number4
Early online date13 Mar 2018
Publication statusPublished - 1 Apr 2018

Structured keywords

  • Centre for Surgical Research


  • Case series
  • Cycling
  • Endofibrosis
  • External iliac artery

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