The JAK/STAT pathway is involved in synaptic plasticity

C Nicolas, SAJ Peineau, M Amici, Z Csaba, A Fafouri, C Javalet, VJ Collett, L Hildebrandt, G Seaton, S-L Choi, S-E Sim, C Bradley, K Lee, M Zhuo, B-K Kaang, P Gressens, P Dournaud, Stephen M Fitzjohn, ZA Bortolotto, K ChoGL Collingridge

Research output: Contribution to journalArticle (Academic Journal)

118 Citations (Scopus)

Abstract

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.
Original languageEnglish
Pages (from-to)374 - 390
Number of pages16
JournalNeuron
Volume73
Issue number2
DOIs
Publication statusPublished - 26 Jan 2012

Bibliographical note

Publisher: Elsevier
Other: Accepted November 2011

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    Nicolas, C., Peineau, SAJ., Amici, M., Csaba, Z., Fafouri, A., Javalet, C., Collett, VJ., Hildebrandt, L., Seaton, G., Choi, S-L., Sim, S-E., Bradley, C., Lee, K., Zhuo, M., Kaang, B-K., Gressens, P., Dournaud, P., Fitzjohn, S. M., Bortolotto, ZA., ... Collingridge, GL. (2012). The JAK/STAT pathway is involved in synaptic plasticity. Neuron, 73(2), 374 - 390. https://doi.org/10.1016/j.neuron.2011.11.024