The JAK/STAT pathway is involved in synaptic plasticity

C Nicolas; SAJ Peineau; M Amici; Z Csaba; A Fafouri; C Javalet; VJ Collett; L Hildebrandt; G Seaton; S-L Choi; S-E Sim; C Bradley; K Lee; M Zhuo; B-K Kaang; P Gressens; P Dournaud; Stephen M Fitzjohn; ZA Bortolotto; K Cho; GL Collingridge

doi:10.1016/j.neuron.2011.11.024

The JAK/STAT pathway is involved in synaptic plasticity

C Nicolas, SAJ Peineau, M Amici, Z Csaba, A Fafouri, C Javalet, VJ Collett, L Hildebrandt, G Seaton, S-L Choi, S-E Sim, C Bradley, K Lee, M Zhuo, B-K Kaang, P Gressens, P Dournaud, Stephen M Fitzjohn, ZA Bortolotto, K ChoGL Collingridge

Research output: Contribution to journal › Article (Academic Journal) › peer-review

158 Citations (Scopus)

Abstract

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.

Translated title of the contribution	The JAK/STAT pathway is involved in synaptic plasticity
Original language	English
Pages (from-to)	374 - 390
Number of pages	16
Journal	Neuron
Volume	73
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2011.11.024
Publication status	Published - 26 Jan 2012

Bibliographical note

Publisher: Elsevier
Other: Accepted November 2011

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10.1016/j.neuron.2011.11.024

http://www.sciencedirect.com/science/article/pii/S0896627312000268

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Nicolas, C., Peineau, SAJ., Amici, M., Csaba, Z., Fafouri, A., Javalet, C., Collett, VJ., Hildebrandt, L., Seaton, G., Choi, S-L., Sim, S-E., Bradley, C., Lee, K., Zhuo, M., Kaang, B-K., Gressens, P., Dournaud, P., Fitzjohn, S. M., Bortolotto, ZA., ... Collingridge, GL. (2012). The JAK/STAT pathway is involved in synaptic plasticity. Neuron, 73(2), 374 - 390. https://doi.org/10.1016/j.neuron.2011.11.024

@article{11586a929e4d44d0a297a1a3407e97fe,

title = "The JAK/STAT pathway is involved in synaptic plasticity",

abstract = "The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.",

author = "C Nicolas and SAJ Peineau and M Amici and Z Csaba and A Fafouri and C Javalet and VJ Collett and L Hildebrandt and G Seaton and S-L Choi and S-E Sim and C Bradley and K Lee and M Zhuo and B-K Kaang and P Gressens and P Dournaud and Fitzjohn, {Stephen M} and ZA Bortolotto and K Cho and GL Collingridge",

note = "Publisher: Elsevier Other: Accepted November 2011",

year = "2012",

month = jan,

day = "26",

doi = "10.1016/j.neuron.2011.11.024",

language = "English",

volume = "73",

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journal = "Neuron",

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Nicolas, C, Peineau, SAJ, Amici, M, Csaba, Z, Fafouri, A, Javalet, C, Collett, VJ, Hildebrandt, L, Seaton, G, Choi, S-L, Sim, S-E, Bradley, C, Lee, K, Zhuo, M, Kaang, B-K, Gressens, P, Dournaud, P, Fitzjohn, SM , Bortolotto, ZA, Cho, K & Collingridge, GL 2012, 'The JAK/STAT pathway is involved in synaptic plasticity', Neuron, vol. 73, no. 2, pp. 374 - 390. https://doi.org/10.1016/j.neuron.2011.11.024

TY - JOUR

T1 - The JAK/STAT pathway is involved in synaptic plasticity

AU - Nicolas, C

AU - Peineau, SAJ

AU - Amici, M

AU - Csaba, Z

AU - Fafouri, A

AU - Javalet, C

AU - Collett, VJ

AU - Hildebrandt, L

AU - Seaton, G

AU - Choi, S-L

AU - Sim, S-E

AU - Bradley, C

AU - Lee, K

AU - Zhuo, M

AU - Kaang, B-K

AU - Gressens, P

AU - Dournaud, P

AU - Fitzjohn, Stephen M

AU - Bortolotto, ZA

AU - Cho, K

AU - Collingridge, GL

N1 - Publisher: Elsevier Other: Accepted November 2011

PY - 2012/1/26

Y1 - 2012/1/26

N2 - The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.

AB - The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.

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U2 - 10.1016/j.neuron.2011.11.024

DO - 10.1016/j.neuron.2011.11.024

M3 - Article (Academic Journal)

C2 - 22284190

VL - 73

SP - 374

EP - 390

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 2

ER -

The JAK/STAT pathway is involved in synaptic plasticity

Abstract

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THE EFFECTS OF ACUTE STRESS ON GLUTAMATE RECEPTOR TRAFFICKING AND SYNAPTIC PLASTICITY IN THE HIPPOCAMPUS

MECHANISMS OF NMDA RECEPTOR DEPENDANT LTP AND LTD IN THE HIPPOCAMPUS

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The JAK/STAT pathway is involved in synaptic plasticity

Abstract

Bibliographical note

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THE EFFECTS OF ACUTE STRESS ON GLUTAMATE RECEPTOR TRAFFICKING AND SYNAPTIC PLASTICITY IN THE HIPPOCAMPUS

MECHANISMS OF NMDA RECEPTOR DEPENDANT LTP AND LTD IN THE HIPPOCAMPUS

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