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The JAK/STAT pathway is involved in synaptic plasticity

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The JAK/STAT pathway is involved in synaptic plasticity. / Nicolas, C; Peineau, SAJ; Amici, M; Csaba, Z; Fafouri, A; Javalet, C; Collett, VJ; Hildebrandt, L; Seaton, G; Choi, S-L; Sim, S-E; Bradley, C; Lee, K; Zhuo, M; Kaang, B-K; Gressens, P; Dournaud, P; Fitzjohn, Stephen M; Bortolotto, ZA; Cho, K; Collingridge, GL.

In: Neuron, Vol. 73, No. 2, 26.01.2012, p. 374 - 390.

Research output: Contribution to journalArticle

Harvard

Nicolas, C, Peineau, SAJ, Amici, M, Csaba, Z, Fafouri, A, Javalet, C, Collett, VJ, Hildebrandt, L, Seaton, G, Choi, S-L, Sim, S-E, Bradley, C, Lee, K, Zhuo, M, Kaang, B-K, Gressens, P, Dournaud, P, Fitzjohn, SM, Bortolotto, ZA, Cho, K & Collingridge, GL 2012, 'The JAK/STAT pathway is involved in synaptic plasticity', Neuron, vol. 73, no. 2, pp. 374 - 390. https://doi.org/10.1016/j.neuron.2011.11.024

APA

Nicolas, C., Peineau, SAJ., Amici, M., Csaba, Z., Fafouri, A., Javalet, C., ... Collingridge, GL. (2012). The JAK/STAT pathway is involved in synaptic plasticity. Neuron, 73(2), 374 - 390. https://doi.org/10.1016/j.neuron.2011.11.024

Vancouver

Nicolas C, Peineau SAJ, Amici M, Csaba Z, Fafouri A, Javalet C et al. The JAK/STAT pathway is involved in synaptic plasticity. Neuron. 2012 Jan 26;73(2):374 - 390. https://doi.org/10.1016/j.neuron.2011.11.024

Author

Nicolas, C ; Peineau, SAJ ; Amici, M ; Csaba, Z ; Fafouri, A ; Javalet, C ; Collett, VJ ; Hildebrandt, L ; Seaton, G ; Choi, S-L ; Sim, S-E ; Bradley, C ; Lee, K ; Zhuo, M ; Kaang, B-K ; Gressens, P ; Dournaud, P ; Fitzjohn, Stephen M ; Bortolotto, ZA ; Cho, K ; Collingridge, GL. / The JAK/STAT pathway is involved in synaptic plasticity. In: Neuron. 2012 ; Vol. 73, No. 2. pp. 374 - 390.

Bibtex

@article{11586a929e4d44d0a297a1a3407e97fe,
title = "The JAK/STAT pathway is involved in synaptic plasticity",
abstract = "The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.",
author = "C Nicolas and SAJ Peineau and M Amici and Z Csaba and A Fafouri and C Javalet and VJ Collett and L Hildebrandt and G Seaton and S-L Choi and S-E Sim and C Bradley and K Lee and M Zhuo and B-K Kaang and P Gressens and P Dournaud and Fitzjohn, {Stephen M} and ZA Bortolotto and K Cho and GL Collingridge",
note = "Publisher: Elsevier Other: Accepted November 2011",
year = "2012",
month = "1",
day = "26",
doi = "10.1016/j.neuron.2011.11.024",
language = "English",
volume = "73",
pages = "374 -- 390",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - The JAK/STAT pathway is involved in synaptic plasticity

AU - Nicolas, C

AU - Peineau, SAJ

AU - Amici, M

AU - Csaba, Z

AU - Fafouri, A

AU - Javalet, C

AU - Collett, VJ

AU - Hildebrandt, L

AU - Seaton, G

AU - Choi, S-L

AU - Sim, S-E

AU - Bradley, C

AU - Lee, K

AU - Zhuo, M

AU - Kaang, B-K

AU - Gressens, P

AU - Dournaud, P

AU - Fitzjohn, Stephen M

AU - Bortolotto, ZA

AU - Cho, K

AU - Collingridge, GL

N1 - Publisher: Elsevier Other: Accepted November 2011

PY - 2012/1/26

Y1 - 2012/1/26

N2 - The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.

AB - The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84863012554&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2011.11.024

DO - 10.1016/j.neuron.2011.11.024

M3 - Article

C2 - 22284190

VL - 73

SP - 374

EP - 390

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 2

ER -