The laboratory mouse and wild immunology

M Viney, L Lazarou, S Abolins

Research output: Contribution to journalArticle (Academic Journal)peer-review

20 Citations (Scopus)
316 Downloads (Pure)

Abstract

The laboratory mouse, Mus musculus domesticus, has been the workhorse of the very successful laboratory study of mammalian immunology. These studies--discovering how the mammalian immune system can work--have allowed the development of the field of wild immunology that is seeking to understand how the immune responses of wild animals contributes to animals' fitness. Remarkably, there have hardly been any studies of the immunology of wild M. musculus domesticus (or of rats, another common laboratory model), but the general finding is that these wild animals are more immunologically responsive, compared with their laboratory domesticated comparators. This difference probably reflects the comparatively greater previous exposure to antigens of these wild-caught animals. There are now excellent prospects for laboratory mouse immunology to make major advances in the field of wild immunology.

Original languageEnglish
Pages (from-to)267-73
Number of pages7
JournalParasite Immunology
Volume37
Issue number5
Early online date9 Oct 2014
DOIs
Publication statusPublished - 27 Apr 2015

Keywords

  • Animals
  • Animals, Laboratory
  • Animals, Wild
  • Mice
  • Rats
  • ecoimmunology
  • fitness
  • Mus
  • wild

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