The Language of Calcium Signaling

Antony N. Dodd, Joerg Kudla, Dale Sanders

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

984 Citations (Scopus)


Ca2+ signals are a core regulator of plant cell physiology and cellular responses to the environment. The channels, pumps, and carriers that underlie Ca2+ homeostasis provide the mechanistic basis for generation of Ca2+ signals by regulating movement of Ca2+ ions between subcellular compartments and between the cell and its extracellular environment. The information encoded within the Ca2+ transients is decoded and transmitted by a toolkit of Ca2+-binding proteins that regulate transcription via Ca2+-responsive promoter elements and that regulate protein phosphorylation. Ca2+-signaling networks have architectural structures comparable to scale-free networks and bow tie networks in computing, and these similarities help explain such properties of Ca2+-signaling networks as robustness, evolvability, and the ability to process multiple signals simultaneously.

Original languageEnglish
Title of host publicationAnnual Review of Plant Biology
Place of PublicationPALO ALTO
PublisherAnnual Reviews
Number of pages28
Publication statusPublished - 2010


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