The lateral cerebellum and visuomotor control

NL Cerminara, AL Edge, DE Marple-Horvat, R Apps*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Abstract

The lateral cerebellum receives an abundance of visual input providing the link between visual and motor control centers. In this review we discuss experiments designed to increase our understanding of how visual inputs to the cerebellum are arranged in relation to the zonal organization of the cerebellar cortex, and how visual inputs are utilized to assist in the regulation of a visually guided movement. On the basis of anatomical and physiological characteristics our findings indicate that the medial-most folium in crus I of the cat lateral cerebellum can be subdivided into at least three functionally distinct zones; from lateral to medial along the length of the folium these correspond to zones D(1), lateral C(3) and C(2). Each zone displays clear differences in olivo-cortico-nuclear connectivity and in the anesthetized animal zones D, and C, both receive powerful visual inuts relayed via the climbing fiber system. Complementary experiments in awake behaving cats found that Purkinje cells located in the D(1) and D(2) zones of crus I exhibit changes in simple spike discharge time locked to target motion during a visually guided reaching task. These changes were unaffected by temporary visual denial of the target, raising the possibility that internally generated feedforward visuomotor control mechanisms are operating, in which a predictive model of the target's motion has been constructed by the CNS.

Original languageEnglish
Title of host publicationCREATING COORDINATION IN THE CEREBELLUM
EditorsCI DeZeeuw, F Cicirata
Place of PublicationAMSTERDAM
PublisherAmsterdam:Elsevier
Pages213-226
Number of pages14
ISBN (Print)0-444-51754-5
DOIs
Publication statusPublished - 2005
EventMeeting on Creating Coordination in the Cerebellum - Catania, Italy
Duration: 2 Oct 20034 Oct 2003

Publication series

NameProgress in Brain Research
PublisherELSEVIER SCIENCE BV
Volume148
ISSN (Print)0079-6123

Conference

ConferenceMeeting on Creating Coordination in the Cerebellum
CountryItaly
CityCatania
Period2/10/034/10/03

Keywords

  • FUNCTIONAL-ORGANIZATION
  • visuomotor
  • CLIMBING FIBER INPUT
  • DENTATE NEURONS
  • EYE-MOVEMENTS
  • climbing fiber
  • PONTINE NUCLEI
  • VISUAL-STIMULI
  • visual
  • inferior olive
  • CORTICAL ZONES
  • MICRO-ORGANIZATION
  • NEURONAL-ACTIVITY
  • HORSERADISH-PEROXIDASE
  • cerebellum

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