The long arm of childhood socioeconomic deprivation on mid‐ to later‐life cognitive trajectories: A cross‐cohort analysis

Ruby S. M. Tsang, John E. Gallacher, Bauermeister Sarah*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)
87 Downloads (Pure)


Earlier studies of the effects of childhood socioeconomic status (SES) on later-life cognitive function consistently report a social gradient in later-life cognitive function. Evidence for their effects on cognitive decline is, however, less clear.

The sample consists of 5324 participants in the Whitehall II study, 8572 in the Health and Retirement Study (HRS), and 1413 in the Kame Project, who completed self-report questionnaires on their early life experiences and underwent repeated cognitive assessments. We characterized cognitive trajectories using latent class mixed models, and explored associations between childhood SES and latent class membership using logistic regressions.

We identified distinct trajectories classes for all cognitive measures examined. Childhood socioeconomic deprivation was associated with an increased likelihood of being in a lower trajectory class.

Our findings support the notions that cognitive aging is a heterogeneous process and early life circumstances may have lasting effects on cognition across the life-course.
Original languageEnglish
Article numbere12322
JournalAlzheimer's & dementia (Amsterdam, Netherlands)
Issue number1
Publication statusPublished - 1 Jun 2022

Bibliographical note

Funding Information:
RT was supported by Dementias Platform UK (DPUK) and all analyses were conducted on the DPUK Data Portal. This study was conducted under DPUK Study 0144 as part of the Early Experience and Dementia Research Programme. The Medical Research Council supports DPUK through grant MR/T0333771.

Publisher Copyright:
© 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.


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