The many faces of SRPK1

Nicholas Bullock, Sebastian Oltean

Research output: Contribution to journalArticle (Academic Journal)peer-review

17 Citations (Scopus)
244 Downloads (Pure)

Abstract

Serine-arginine protein kinase 1 (SRPK1) phosphorylates proteins involved in the regulation of several mRNA processing pathways including alternative splicing. SRPK1 has been recently reported to be over-expressed in multiple cancers including prostate, breast, lung and glioma. Several studies have shown that inhibition of SRPK1 has anti-tumoural effects and consequently SRPK1 has become a new candidate for targeted therapies. Interestingly, in terms of molecular mechanism, SRPK1 seems to act heterogeneously and has been reported to affect several processes in different cancers, for example angiogenesis in prostate and colon cancer, apoptosis in breast and colon cancer and migration in breast cancer. A recent report adds to this puzzle, showing that the main effect of overexpression of SRPK1 in non-small-cell lung carcinoma is to stimulate a stem cell-like phenotype. This pleiotropy might be related to preferential activation of different downstream signaling pathways by SRPK1 in various cancers.
Original languageEnglish
Pages (from-to)437–440
Number of pages4
JournalJournal of Pathology
Volume241
Issue number4
Early online date1 Feb 2017
DOIs
Publication statusPublished - Mar 2017

Keywords

  • Cancer
  • Wnt/β-catenin signaling
  • SRPK1
  • stem cell
  • NSCLC

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