The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine

Sara Lawrence-Mills; David Hughes; Melanie J Hezzell; Matthew J Butler; Chris R Neal; R R Foster; Gavin I Welsh; Natalie C Finch

doi:10.1016/j.tvjl.2022.105843

The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine

Sara Lawrence-Mills^*, David Hughes, Melanie J Hezzell, Matthew J Butler, Chris R Neal, R R Foster, Gavin I Welsh, Natalie C Finch

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

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Abstract

The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its structure, essential functions, and evidence for its role in disease. We highlight the lack of studies regarding the eGlx in cats and dogs, particularly in naturally occurring diseases. Importantly, we discuss techniques to aid its study, which can be applied to veterinary species. Finally, we present targeted therapies aimed at preserving, and in some cases, restoring damaged eGlx.

Original language	English
Article number	105843
Journal	Veterinary Journal
Volume	285
Early online date	31 May 2022
DOIs	https://doi.org/10.1016/j.tvjl.2022.105843
Publication status	Published - 1 Jul 2022

Bibliographical note

Funding Information:
This research was funded in whole, or in part, by the Wellcome Trust ( 204813/Z/16/Z ). None of the authors of this paper has any other financial or personal relationship with other people or organisations that could inappropriately influence or bias the content of the paper.

Publisher Copyright:
© 2022 The Authors

Keywords

Detection
Diagnosis
Disease
Physiology
Visualisation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine",

abstract = "The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its structure, essential functions, and evidence for its role in disease. We highlight the lack of studies regarding the eGlx in cats and dogs, particularly in naturally occurring diseases. Importantly, we discuss techniques to aid its study, which can be applied to veterinary species. Finally, we present targeted therapies aimed at preserving, and in some cases, restoring damaged eGlx. ",

keywords = "Detection, Diagnosis, Disease, Physiology, Visualisation",

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note = "Funding Information: This research was funded in whole, or in part, by the Wellcome Trust ( 204813/Z/16/Z ). None of the authors of this paper has any other financial or personal relationship with other people or organisations that could inappropriately influence or bias the content of the paper. Publisher Copyright: {\textcopyright} 2022 The Authors",

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AU - Lawrence-Mills, Sara

AU - Hughes, David

AU - Hezzell, Melanie J

AU - Butler, Matthew J

AU - Neal, Chris R

AU - Foster, R R

AU - Welsh, Gavin I

AU - Finch, Natalie C

N1 - Funding Information: This research was funded in whole, or in part, by the Wellcome Trust ( 204813/Z/16/Z ). None of the authors of this paper has any other financial or personal relationship with other people or organisations that could inappropriately influence or bias the content of the paper. Publisher Copyright: © 2022 The Authors

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N2 - The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its structure, essential functions, and evidence for its role in disease. We highlight the lack of studies regarding the eGlx in cats and dogs, particularly in naturally occurring diseases. Importantly, we discuss techniques to aid its study, which can be applied to veterinary species. Finally, we present targeted therapies aimed at preserving, and in some cases, restoring damaged eGlx.

AB - The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its structure, essential functions, and evidence for its role in disease. We highlight the lack of studies regarding the eGlx in cats and dogs, particularly in naturally occurring diseases. Importantly, we discuss techniques to aid its study, which can be applied to veterinary species. Finally, we present targeted therapies aimed at preserving, and in some cases, restoring damaged eGlx.

KW - Detection

KW - Diagnosis

KW - Disease

KW - Physiology

KW - Visualisation

U2 - 10.1016/j.tvjl.2022.105843

DO - 10.1016/j.tvjl.2022.105843

M3 - Review article (Academic Journal)

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JO - Veterinary Journal

JF - Veterinary Journal

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ER -

The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine

Abstract

Bibliographical note

Keywords

UN SDGs

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