The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine

Sara Lawrence-Mills*, David Hughes, Melanie J Hezzell, Matthew J Butler, Chris R Neal, R R Foster, Gavin I Welsh, Natalie C Finch

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

4 Citations (Scopus)
89 Downloads (Pure)


The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its structure, essential functions, and evidence for its role in disease. We highlight the lack of studies regarding the eGlx in cats and dogs, particularly in naturally occurring diseases. Importantly, we discuss techniques to aid its study, which can be applied to veterinary species. Finally, we present targeted therapies aimed at preserving, and in some cases, restoring damaged eGlx.
Original languageEnglish
Article number105843
JournalVeterinary Journal
Early online date31 May 2022
Publication statusPublished - 1 Jul 2022

Bibliographical note

Funding Information:
This research was funded in whole, or in part, by the Wellcome Trust ( 204813/Z/16/Z ). None of the authors of this paper has any other financial or personal relationship with other people or organisations that could inappropriately influence or bias the content of the paper.

Publisher Copyright:
© 2022 The Authors


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