The mitochondrial KATP channel-Fact or fiction?

KD Garlid, AP Halestrap

Research output: Contribution to journalArticle (Academic Journal)peer-review

55 Citations (Scopus)

Abstract

The mitochondrial ATP-dependent K+ channel (mitoKATP) is widely considered by many to play a central role in cardioprotection by ischemic and pharmacological preconditioning and by ischemic postconditioning. Nevertheless, several laboratories have questioned the existence of mitoKATP. This article summarizes the evidence for and against and addresses two key questions: How strong is the evidence for the presence of a KATP channel in mitochondria? Are the pharmacological agents used to modulate mitoKATP activity sufficiently specific to allow the role of these channels in cardioprotection to be established?
Translated title of the contributionThe mitochondrial KATP channel-Fact or fiction?
Original languageEnglish
Pages (from-to)578 - 583
Number of pages6
JournalJournal of Molecular and Cellular Cardiology
Volume52
DOIs
Publication statusPublished - Mar 2012

Bibliographical note

Other: First published on-line 2nd January 2012

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