The mitochondrial KATP channel-Fact or fiction?

KD Garlid; AP Halestrap

doi:10.1016/j.yjmcc.2011.12.011

The mitochondrial K_ATP channel-Fact or fiction?

KD Garlid, AP Halestrap

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Abstract

The mitochondrial ATP-dependent K⁺ channel (mitoK_ATP) is widely considered by many to play a central role in cardioprotection by ischemic and pharmacological preconditioning and by ischemic postconditioning. Nevertheless, several laboratories have questioned the existence of mitoK_ATP. This article summarizes the evidence for and against and addresses two key questions: How strong is the evidence for the presence of a K_ATP channel in mitochondria? Are the pharmacological agents used to modulate mitoK_ATP activity sufficiently specific to allow the role of these channels in cardioprotection to be established?

Translated title of the contribution	The mitochondrial K_ATP channel-Fact or fiction?
Original language	English
Pages (from-to)	578 - 583
Number of pages	6
Journal	Journal of Molecular and Cellular Cardiology
Volume	52
DOIs	https://doi.org/10.1016/j.yjmcc.2011.12.011
Publication status	Published - Mar 2012

Bibliographical note

Other: First published on-line 2nd January 2012

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10.1016/j.yjmcc.2011.12.011

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@article{f5e160fc639e4ba3a0dd44ceed56340b,

title = "The mitochondrial KATP channel-Fact or fiction?",

abstract = "The mitochondrial ATP-dependent K+ channel (mitoKATP) is widely considered by many to play a central role in cardioprotection by ischemic and pharmacological preconditioning and by ischemic postconditioning. Nevertheless, several laboratories have questioned the existence of mitoKATP. This article summarizes the evidence for and against and addresses two key questions: How strong is the evidence for the presence of a KATP channel in mitochondria? Are the pharmacological agents used to modulate mitoKATP activity sufficiently specific to allow the role of these channels in cardioprotection to be established?",

author = "KD Garlid and AP Halestrap",

note = "Other: First published on-line 2nd January 2012",

year = "2012",

month = mar,

doi = "10.1016/j.yjmcc.2011.12.011",

language = "English",

volume = "52",

pages = "578 -- 583",

journal = "Journal of Molecular and Cellular Cardiology",