The Mitochondrial Permeability Transition Pore – a Regulator of the Resistance of the Heart to Reperfusion

N. V. Naryzhnaya; L. N. Maslov; Yu. B. Lishmanov; E. A. Nesterov; A. S. Yaggi; M. S. Suleiman

doi:10.1007/s11055-019-00823-y

The Mitochondrial Permeability Transition Pore – a Regulator of the Resistance of the Heart to Reperfusion

N. V. Naryzhnaya^*, L. N. Maslov, Yu. B. Lishmanov, E. A. Nesterov, A. S. Yaggi, M. S. Suleiman

^*Corresponding author for this work

Bristol Medical School (THS)

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Abstract

The most important event in the formation of reperfusion injury to the heart has been shown to be the opening of mitochondrial permeability transition pores (mPTP). mPTP opening is followed by activation of apoptosis, necroptosis, and cardiomyocyte death. Experimental studies have shown that inhibition of mPTP opening decreases infarct size and that conditioning actions on the myocardium are mediated via decreases in the sensitivity of mPTP to opening factors. The present article reviews existing data on the structure and regulation of mPTP in conditions of reperfusion injury to the heart.

Original language	English
Pages (from-to)	943-953
Number of pages	11
Journal	Neuroscience and Behavioral Physiology
Volume	49
Issue number	8
DOIs	https://doi.org/10.1007/s11055-019-00823-y
Publication status	Published - 19 Nov 2019

Keywords

mitochondria
MPT pores
myocardium
reperfusion

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title = "The Mitochondrial Permeability Transition Pore – a Regulator of the Resistance of the Heart to Reperfusion",

abstract = "The most important event in the formation of reperfusion injury to the heart has been shown to be the opening of mitochondrial permeability transition pores (mPTP). mPTP opening is followed by activation of apoptosis, necroptosis, and cardiomyocyte death. Experimental studies have shown that inhibition of mPTP opening decreases infarct size and that conditioning actions on the myocardium are mediated via decreases in the sensitivity of mPTP to opening factors. The present article reviews existing data on the structure and regulation of mPTP in conditions of reperfusion injury to the heart.",

keywords = "mitochondria, MPT pores, myocardium, reperfusion",

author = "Naryzhnaya, {N. V.} and Maslov, {L. N.} and Lishmanov, {Yu. B.} and Nesterov, {E. A.} and Yaggi, {A. S.} and Suleiman, {M. S.}",

year = "2019",

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T1 - The Mitochondrial Permeability Transition Pore – a Regulator of the Resistance of the Heart to Reperfusion

AU - Naryzhnaya, N. V.

AU - Maslov, L. N.

AU - Lishmanov, Yu. B.

AU - Nesterov, E. A.

AU - Yaggi, A. S.

AU - Suleiman, M. S.

PY - 2019/11/19

Y1 - 2019/11/19

N2 - The most important event in the formation of reperfusion injury to the heart has been shown to be the opening of mitochondrial permeability transition pores (mPTP). mPTP opening is followed by activation of apoptosis, necroptosis, and cardiomyocyte death. Experimental studies have shown that inhibition of mPTP opening decreases infarct size and that conditioning actions on the myocardium are mediated via decreases in the sensitivity of mPTP to opening factors. The present article reviews existing data on the structure and regulation of mPTP in conditions of reperfusion injury to the heart.

AB - The most important event in the formation of reperfusion injury to the heart has been shown to be the opening of mitochondrial permeability transition pores (mPTP). mPTP opening is followed by activation of apoptosis, necroptosis, and cardiomyocyte death. Experimental studies have shown that inhibition of mPTP opening decreases infarct size and that conditioning actions on the myocardium are mediated via decreases in the sensitivity of mPTP to opening factors. The present article reviews existing data on the structure and regulation of mPTP in conditions of reperfusion injury to the heart.

KW - mitochondria

KW - MPT pores

KW - myocardium

KW - reperfusion

UR - http://www.scopus.com/inward/record.url?scp=85075372315&partnerID=8YFLogxK

U2 - 10.1007/s11055-019-00823-y

DO - 10.1007/s11055-019-00823-y

M3 - Review article (Academic Journal)

AN - SCOPUS:85075372315

SN - 0097-0549

VL - 49

SP - 943

EP - 953

JO - Neuroscience and Behavioral Physiology

JF - Neuroscience and Behavioral Physiology

IS - 8

ER -

The Mitochondrial Permeability Transition Pore – a Regulator of the Resistance of the Heart to Reperfusion

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