The molecular biology of pelvi-ureteric junction obstruction

Laura Jackson*, Mark Woodward, Richard J. Coward

*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

23 Citations (Scopus)
374 Downloads (Pure)

Abstract

Over recent years routine ultrasound scanning has identified increasing numbers of neonates as having hydronephrosis and pelvi-ureteric junction obstruction (PUJO). This patient group presents a diagnostic and management challenge for paediatric nephrologists and urologists. In this review we consider the known molecular mechanisms underpinning PUJO and review the potential of utilising this information to develop novel therapeutics and diagnostic biomarkers to improve the care of children with this disorder.

Original languageEnglish
Pages (from-to)1-19
Number of pages19
JournalPediatric Nephrology
DOIs
Publication statusPublished - 13 Mar 2017

Keywords

  • Aetiology
  • Biomarker
  • Hydronephrosis
  • Molecular biology
  • Pelvi-ureteric junction obstruction

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  • Full-text PDF (published version)

    This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Springer Link at https://link.springer.com/article/10.1007%2Fs00467-017-3629-0#Ethics. Please refer to any applicable terms of use of the publisher.

    Final published version, 1.75 MBLicence: CC BY

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