The molecular genetics of sirtuins: association with human longevity and age-related diseases

L Polito, PG Kehoe, G Forloni, D Albani

Research output: Contribution to journalReview article (Academic Journal)

25 Citations (Scopus)

Abstract

The sirtuins are a family of proteins remarkably conserved from yeast to humans. In organisms such as yeast, worms and flies it is quite well established that the activity of sirtuins prolongs lifespan. As a result of promising findings in simple organisms, sirtuins are now investigated in higher organisms in relation to the ageing process. In mammals there are seven different sirtuin proteins each encoded by individual genes (SIRT1-7). Although sirtuins share a highly conserved catalytic domain, they differ in their biological function. Some mammalian sirtuins have been implicated in different ageing pathways and their modulation has been deemed to be beneficial in different models of age-associated diseases. Overall, sirtuins could contribute to mechanisms of human longevity and avoid or delay the onset of age-associated disorders. Here we review and discuss the potential impact of genetic variation in the sirtuin genes in relation to human longevity and age-related diseases.
Translated title of the contributionThe molecular genetics of sirtuins: association with human longevity and age-related diseases
Original languageEnglish
Pages (from-to)214 - 225
Number of pages12
JournalInt J Mol Epidemiol Genet
Volume1
Publication statusPublished - Jun 2010

Bibliographical note

Publisher: e-Century Publishing Corporation

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