TY - JOUR
T1 - The mTORC1-autophagy pathway is a target for senescent cell elimination
AU - Kucheryavenko, Olena
AU - Nelson, Glyn
AU - von Zglinicki, Thomas
AU - Korolchuk, Viktor I
AU - Carroll, Bernadette
PY - 2019/6
Y1 - 2019/6
N2 - Cellular senescence has recently been established as a key driver of organismal ageing. The state of senescence is controlled by extensive rewiring of signalling pathways, at the heart of which lies the mammalian Target of Rapamycin Complex I (mTORC1). Here we discuss recent publications aiming to establish the mechanisms by which mTORC1 drives the senescence program. In particular, we highlight our data indicating that mTORC1 can be used as a target for senescence cell elimination in vitro. Suppression of mTORC1 is known to extend lifespan of yeast, worms, flies and some mouse models and our proof-of-concept experiments suggest that it can also act by reducing senescent cell load in vivo.
AB - Cellular senescence has recently been established as a key driver of organismal ageing. The state of senescence is controlled by extensive rewiring of signalling pathways, at the heart of which lies the mammalian Target of Rapamycin Complex I (mTORC1). Here we discuss recent publications aiming to establish the mechanisms by which mTORC1 drives the senescence program. In particular, we highlight our data indicating that mTORC1 can be used as a target for senescence cell elimination in vitro. Suppression of mTORC1 is known to extend lifespan of yeast, worms, flies and some mouse models and our proof-of-concept experiments suggest that it can also act by reducing senescent cell load in vivo.
U2 - 10.1007/s10522-019-09802-9
DO - 10.1007/s10522-019-09802-9
M3 - Article (Academic Journal)
C2 - 30798505
SN - 1389-5729
VL - 20
SP - 331
EP - 335
JO - Biogerontology
JF - Biogerontology
IS - 3
ER -