The mTORC1-autophagy pathway is a target for senescent cell elimination

Olena Kucheryavenko, Glyn Nelson, Thomas von Zglinicki, Viktor I Korolchuk, Bernadette Carroll

Research output: Contribution to journalArticle (Academic Journal)peer-review

10 Citations (Scopus)
145 Downloads (Pure)

Abstract

Cellular senescence has recently been established as a key driver of organismal ageing. The state of senescence is controlled by extensive rewiring of signalling pathways, at the heart of which lies the mammalian Target of Rapamycin Complex I (mTORC1). Here we discuss recent publications aiming to establish the mechanisms by which mTORC1 drives the senescence program. In particular, we highlight our data indicating that mTORC1 can be used as a target for senescence cell elimination in vitro. Suppression of mTORC1 is known to extend lifespan of yeast, worms, flies and some mouse models and our proof-of-concept experiments suggest that it can also act by reducing senescent cell load in vivo.

Original languageEnglish
Pages (from-to)331-335
Number of pages5
JournalBiogerontology
Volume20
Issue number3
Early online date23 Feb 2019
DOIs
Publication statusPublished - Jun 2019

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