Research output per year
Research output per year
Abstract
Introduction
Neoadjuvant systemic therapy (NST) has several potential advantages in the treatment of breast cancer. However, there is currently considerable variation in NST use across the UK. The NeST study is a national, prospective, multicentre cohort study that will investigate current patterns of care with respect to NST in the UK.
Methods and Analysis
Phase 1 – a national practice questionnaire (NPQ) to survey current practice
Phase 2 – a multi-centre prospective cohort study of breast cancer patients, undergoing NST
Women undergoing NST as their MDT recommended primary breast cancer treatment between December 2017 - May 2018 will be included. The breast surgery and oncological professional associations and the trainee research collaborative networks will encourage participation by all breast cancer centres.
Patient demographics, radiological, oncological, surgical and pathological data will be collected, including complications and the need for further intervention/treatment. Data will be collated to establish current practice in the UK, regarding NST usage and variability of access and provision of these therapies. Prospective data on 600 patients from ∼50 centres are anticipated.
Trial registration: ISRCTN11160072
Ethics and Dissemination
Research ethics approval is not required for this study, as per the online Health Research Authority decision tool. The information obtained will provide valuable insights to help patients make informed decisions about their treatment. These data should establish current practice in the UK concerning NST, inform future service delivery as well as identifying further research questions.
This protocol will be disseminated through the Mammary Fold Academic Research Collaborative (MFAC), the Reconstructive Surgery Trials Network and the Association of Breast Surgery. Participating units will have access to their own data and collective results will be presented at relevant conferences and published in appropriate peer-reviewed journals, as well as being made accessible to relevant patient groups.
Neoadjuvant systemic therapy (NST) has several potential advantages in the treatment of breast cancer. However, there is currently considerable variation in NST use across the UK. The NeST study is a national, prospective, multicentre cohort study that will investigate current patterns of care with respect to NST in the UK.
Methods and Analysis
Phase 1 – a national practice questionnaire (NPQ) to survey current practice
Phase 2 – a multi-centre prospective cohort study of breast cancer patients, undergoing NST
Women undergoing NST as their MDT recommended primary breast cancer treatment between December 2017 - May 2018 will be included. The breast surgery and oncological professional associations and the trainee research collaborative networks will encourage participation by all breast cancer centres.
Patient demographics, radiological, oncological, surgical and pathological data will be collected, including complications and the need for further intervention/treatment. Data will be collated to establish current practice in the UK, regarding NST usage and variability of access and provision of these therapies. Prospective data on 600 patients from ∼50 centres are anticipated.
Trial registration: ISRCTN11160072
Ethics and Dissemination
Research ethics approval is not required for this study, as per the online Health Research Authority decision tool. The information obtained will provide valuable insights to help patients make informed decisions about their treatment. These data should establish current practice in the UK concerning NST, inform future service delivery as well as identifying further research questions.
This protocol will be disseminated through the Mammary Fold Academic Research Collaborative (MFAC), the Reconstructive Surgery Trials Network and the Association of Breast Surgery. Participating units will have access to their own data and collective results will be presented at relevant conferences and published in appropriate peer-reviewed journals, as well as being made accessible to relevant patient groups.
| Original language | English |
|---|---|
| Journal | International Journal of Surgery Protocols |
| Early online date | 11 Nov 2019 |
| DOIs | |
| Publication status | E-pub ahead of print - 11 Nov 2019 |
Keywords
- breast cancer
- neoadjuvant chemotherapy
- neoadjuvant endocrine therapy
- surgery
- pathology
- radiology
- patterns of care
- outcomes
Access to Document
- Full-text PDF (author’s accepted manuscript)
This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.isjp.2019.10.002 . Please refer to any applicable terms of use of the publisher.
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Dive into the research topics of 'The NeST (neoadjuvant systemic therapy in breast cancer) study: protocol for a prospective multi-centre cohort study to assess the current utilization and short-term outcomes of neoadjuvant systemic therapies in breast cancer '. Together they form a unique fingerprint.Research output
- 6 Citations
- 2 Article (Academic Journal)
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Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study
Fatayer, H., O'Connell, R., Bannon, F., Coles, C., Copson, E., Cutress, R., Dave, R., Gardiner, M., Grayson, M., Holcombe, C., Irshad, S., Irwin, G., O'Brien, C., Palmieri, C., Shaaban, A., Sharma, N., Singh, J., Whitehead, I., Potter, S. & McIntosh, S., 1 Sept 2022, In: British Journal of Surgery. 109, 9, p. 800–803 4 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile7 Citations (Scopus)85 Downloads (Pure) -
The NeST (Neoadjuvant systemic therapy in breast cancer) study: National Practice Questionnaire of United Kingdom multi-disciplinary decision making
NeST Study Research Collaborative, Whitehead, I., Irwin, G. W., Bannon, F., Coles, C. E., Copson, E., Cutress, R. I., Dave, R. V., Gardiner, M. D., Grayson, M., Holcombe, C., Irshad, S., O'Brien, C., O'Connell, R. L., Palmieri, C., Shaaban, A. M., Sharma, N., Singh, J. K., Potter, S. & McIntosh, S. A., 22 Jan 2021, In: BMC Cancer. 21, p. 90 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile11 Citations (Scopus)56 Downloads (Pure)