The neural correlates of inhibitory control in 10-month-old infants: A functional near-infrared spectroscopy study

Abigail Fiske; Carina de Klerk; Katie Y.K. Lui; Liam Collins-Jones; Alexandra Hendry; Isobel Greenhalgh; Anna Hall; Gaia Scerif; Henrik Dvergsdal; Karla Holmboe

doi:10.1016/j.neuroimage.2022.119241

The neural correlates of inhibitory control in 10-month-old infants: A functional near-infrared spectroscopy study

Abigail Fiske^*, Carina de Klerk, Katie Y.K. Lui, Liam Collins-Jones, Alexandra Hendry, Isobel Greenhalgh, Anna Hall, Gaia Scerif, Henrik Dvergsdal, Karla Holmboe

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Inhibitory control, a core executive function, emerges in infancy and develops rapidly across childhood. Methodological limitations have meant that studies investigating the neural correlates underlying inhibitory control in infancy are rare. Employing functional near-infrared spectroscopy alongside a novel touchscreen task that measures response inhibition, this study aimed to uncover the neural underpinnings of inhibitory control in 10-month-old infants (N = 135). We found that when inhibition was required, the right prefrontal and parietal cortices were more activated than when there was no inhibitory demand. This demonstrates that inhibitory control in infants as young as 10 months of age is supported by similar brain areas as in older children and adults. With this study we have lowered the age-boundary for localising the neural substrates of response inhibition to the first year of life.

Original language	English
Article number	119241
Number of pages	14
Journal	NeuroImage
Volume	257
Early online date	7 May 2022
DOIs	https://doi.org/10.1016/j.neuroimage.2022.119241
Publication status	Published - 15 Aug 2022

Bibliographical note

Funding Information:
This research was funded by the UK Medical Research Council (MR/N008626/1, PI: Karla Holmboe) and by Abigail Fiske's UK Medical Research Council Industrial Collaborative Awards in Science and Engineering (iCASE) studentship. The funder was not involved in the conceptualisation, design, data collection, analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2022

Keywords

Executive function
Response inhibition
Infancy
Functional near-infrared spectroscopy
Prefrontal cortex
Parietal cortex

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10.1016/j.neuroimage.2022.119241

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title = "The neural correlates of inhibitory control in 10-month-old infants: A functional near-infrared spectroscopy study",

abstract = "Inhibitory control, a core executive function, emerges in infancy and develops rapidly across childhood. Methodological limitations have meant that studies investigating the neural correlates underlying inhibitory control in infancy are rare. Employing functional near-infrared spectroscopy alongside a novel touchscreen task that measures response inhibition, this study aimed to uncover the neural underpinnings of inhibitory control in 10-month-old infants (N = 135). We found that when inhibition was required, the right prefrontal and parietal cortices were more activated than when there was no inhibitory demand. This demonstrates that inhibitory control in infants as young as 10 months of age is supported by similar brain areas as in older children and adults. With this study we have lowered the age-boundary for localising the neural substrates of response inhibition to the first year of life.",

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author = "Abigail Fiske and Klerk, {Carina de} and Lui, {Katie Y.K.} and Liam Collins-Jones and Alexandra Hendry and Isobel Greenhalgh and Anna Hall and Gaia Scerif and Henrik Dvergsdal and Karla Holmboe",

note = "Funding Information: This research was funded by the UK Medical Research Council (MR/N008626/1, PI: Karla Holmboe) and by Abigail Fiske's UK Medical Research Council Industrial Collaborative Awards in Science and Engineering (iCASE) studentship. The funder was not involved in the conceptualisation, design, data collection, analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2022",

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T2 - A functional near-infrared spectroscopy study

AU - Fiske, Abigail

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AU - Lui, Katie Y.K.

AU - Collins-Jones, Liam

AU - Hendry, Alexandra

AU - Greenhalgh, Isobel

AU - Hall, Anna

AU - Scerif, Gaia

AU - Dvergsdal, Henrik

AU - Holmboe, Karla

N1 - Funding Information: This research was funded by the UK Medical Research Council (MR/N008626/1, PI: Karla Holmboe) and by Abigail Fiske's UK Medical Research Council Industrial Collaborative Awards in Science and Engineering (iCASE) studentship. The funder was not involved in the conceptualisation, design, data collection, analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022

PY - 2022/8/15

Y1 - 2022/8/15

N2 - Inhibitory control, a core executive function, emerges in infancy and develops rapidly across childhood. Methodological limitations have meant that studies investigating the neural correlates underlying inhibitory control in infancy are rare. Employing functional near-infrared spectroscopy alongside a novel touchscreen task that measures response inhibition, this study aimed to uncover the neural underpinnings of inhibitory control in 10-month-old infants (N = 135). We found that when inhibition was required, the right prefrontal and parietal cortices were more activated than when there was no inhibitory demand. This demonstrates that inhibitory control in infants as young as 10 months of age is supported by similar brain areas as in older children and adults. With this study we have lowered the age-boundary for localising the neural substrates of response inhibition to the first year of life.

AB - Inhibitory control, a core executive function, emerges in infancy and develops rapidly across childhood. Methodological limitations have meant that studies investigating the neural correlates underlying inhibitory control in infancy are rare. Employing functional near-infrared spectroscopy alongside a novel touchscreen task that measures response inhibition, this study aimed to uncover the neural underpinnings of inhibitory control in 10-month-old infants (N = 135). We found that when inhibition was required, the right prefrontal and parietal cortices were more activated than when there was no inhibitory demand. This demonstrates that inhibitory control in infants as young as 10 months of age is supported by similar brain areas as in older children and adults. With this study we have lowered the age-boundary for localising the neural substrates of response inhibition to the first year of life.

KW - Executive function

KW - Response inhibition

KW - Infancy

KW - Functional near-infrared spectroscopy

KW - Prefrontal cortex

KW - Parietal cortex

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DO - 10.1016/j.neuroimage.2022.119241

M3 - Article (Academic Journal)

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VL - 257

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

M1 - 119241

ER -

The neural correlates of inhibitory control in 10-month-old infants: A functional near-infrared spectroscopy study

Abstract

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Keywords

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