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Abstract
How does the cerebellum, the brain's largest sensorimotor structure, contribute to complex behaviors essential to survival? While we know much about the role of limbic and closely associated brainstem structures in relation to a variety of emotional, sensory, or motivational stimuli, we know very little about how these circuits interact with the cerebellum to generate appropriate patterns of behavioral response. Here we focus on evidence suggesting that the olivo-cerebellar system may link to survival networks via interactions with the midbrain periaqueductal gray, a structure with a well known role in expression of survival responses. As a result of this interaction we argue that, in addition to important roles in motor control, the inferior olive, and related olivo-cortico-nuclear circuits, should be considered part of a larger network of brain structures involved in coordinating survival behavior through the selective relaying of "teaching signals" arising from higher centers associated with emotional behaviors.
Original language | English |
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Article number | 72 |
Pages (from-to) | 72 |
Number of pages | 7 |
Journal | Frontiers in Neural Circuits |
Volume | 7 |
DOIs | |
Publication status | Published - 23 Apr 2013 |
Keywords
- cerebellum
- inferior olive
- periaqueductal gray
- survival
- modules
- MIDBRAIN PERIAQUEDUCTAL GRAY
- TRANSCRANIAL MAGNETIC STIMULATION
- UNMYELINATED HEAT NOCICEPTORS
- PONTINE RETICULAR-FORMATION
- DORSAL-HORN NEURONS
- COLUMNAR ORGANIZATION
- CONDITIONED FEAR
- INFERIOR OLIVE
- EMOTIONAL EXPRESSION
- NEUROLOGICAL DISEASE
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Dive into the research topics of 'The olivo-cerebellar system and its relationship to survival circuits'. Together they form a unique fingerprint.Projects
- 1 Finished
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ACTIVE AND PASSIVE COPING STRATEGIES: THE PERIAQUEDUCTAL GREY TO CEREBELLAR LINK
Lumb, B. M. (Principal Investigator)
1/03/09 → 1/09/13
Project: Research