The ORACLE Children Study: Educational outcomes at 11 years of age following antenatal prescription of erythromycin or co-amoxiclav

Neil Marlow*, Hannah Bower, David Jones, Peter Brocklehurst, Sara Kenyon, Katie E Pike, David Taylor, Alison Salt

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

6 Citations (Scopus)
279 Downloads (Pure)

Abstract

Background Antibiotics used for women in spontaneous preterm labour without overt infection, in contrast to those with preterm rupture of membranes, are associated with altered functional outcomes in their children. Methods From the National Pupil Database, we used Key Stage 2 scores, national test scores in school year 6 at 11 years of age, to explore the hypothesis that erythromycin and co-amoxiclav were associated with poorer educational outcomes within the ORACLE Children Study. Results Anonymised scores for 97% of surviving children born to mothers recruited to ORACLE and resident in England were analysed against treatment group adjusting for key available socio-demographic potential confounders. No association with crude or with adjusted scores for English, mathematics or science was observed by maternal antibiotic group in either women with preterm rupture of membranes or spontaneous preterm labour with intact membranes. While the proportion receiving special educational needs was similar in each group (range 31.6-34.4%), it was higher than the national rate of 19%. Conclusions Despite evidence that antibiotics are associated with increased functional impairment at 7 years, educational test scores and special needs at 11 years of age show no differences between trial groups. Trial registration number ISCRT Number 52995660 (original ORACLE trial number).

Original languageEnglish
Pages (from-to)F131-F135
Number of pages5
JournalArchives of Disease in Childhood
Volume102
Issue number2
Early online date11 Aug 2016
DOIs
Publication statusPublished - Mar 2017

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