Projects per year
Chronic pain is highly comorbid with affective disorders, including major depressive disorder (MDD). A core feature of MDD is a loss of interest in previously rewarding activities. MDD is also associated with negative affective biases where cognitive processes are modulated by affective state. Previous work from our laboratory has shown that reward-related learning and memory is impaired in rodent models of depression generated through a variety of different manipulations. This study investigated different aspects of reward-related behaviour in a rodent model of chronic pain, the partial saphenous nerve injury (PSNI). Using our reward learning assay, an impairment in reward learning was observed with no difference in sucrose preference, consistent with a lack of effect on reward sensitivity and similar to the effects seen in depression models. In a successive negative contrast task, chronic pain was not associated with changes in motivation for reward either under normal conditions or when reward was devalued although both sham and PSNI groups exhibited the expected negative contrast effect. In the affective bias test (ABT), PSNI rats developed a positive affective bias when treated with gabapentin, an effect not seen in the controls suggesting an association with the antinociceptive effects of the drug inducing a relatively more positive affective state. Together, these data suggest that there are changes in reward-related cognition in this chronic pain model consistent with previous findings in rodent models of depression. The effects seen with gabapentin suggest that pain associated negative affective state may be remediated by this atypical analgesic.
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- 1 Finished
The neurobiology of cognitive affective biases in depression and their role in antidepressant therapy
2/06/14 → 1/09/17