The physiological functions of central nervous system pericytes and a potential role in pain

Nicholas Beazley-Long; Alexandra M. Durrant; Matthew N. Swift; Lucy F. Donaldson

doi:10.12688/f1000research.13548.1

The physiological functions of central nervous system pericytes and a potential role in pain

Nicholas Beazley-Long^*, Alexandra M. Durrant, Matthew N. Swift, Lucy F. Donaldson

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

4 Citations (Scopus)

Abstract

Central nervous system (CNS) pericytes regulate critical functions of the neurovascular unit in health and disease. CNS pericytes are an attractive pharmacological target for their position within the neurovasculature and for their role in neuroinflammation. Whether the function of CNS pericytes also affects pain states and nociceptive mechanisms is currently not understood. Could it be that pericytes hold the key to pain associated with CNS blood vessel dysfunction? This article reviews recent findings on the important physiological functions of CNS pericytes and highlights how these neurovascular functions could be linked to pain states.

Original language	English
Article number	341
Journal	F1000Research
Volume	7
DOIs	https://doi.org/10.12688/f1000research.13548.1
Publication status	Published - 2018

Bibliographical note

Publisher Copyright:
© 2018 Beazley-Long N et al.

Keywords

Central Nervous System
Pain
Pericytes

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10.12688/f1000research.13548.1

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abstract = "Central nervous system (CNS) pericytes regulate critical functions of the neurovascular unit in health and disease. CNS pericytes are an attractive pharmacological target for their position within the neurovasculature and for their role in neuroinflammation. Whether the function of CNS pericytes also affects pain states and nociceptive mechanisms is currently not understood. Could it be that pericytes hold the key to pain associated with CNS blood vessel dysfunction? This article reviews recent findings on the important physiological functions of CNS pericytes and highlights how these neurovascular functions could be linked to pain states.",

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AU - Beazley-Long, Nicholas

AU - Durrant, Alexandra M.

AU - Swift, Matthew N.

AU - Donaldson, Lucy F.

PY - 2018

Y1 - 2018

N2 - Central nervous system (CNS) pericytes regulate critical functions of the neurovascular unit in health and disease. CNS pericytes are an attractive pharmacological target for their position within the neurovasculature and for their role in neuroinflammation. Whether the function of CNS pericytes also affects pain states and nociceptive mechanisms is currently not understood. Could it be that pericytes hold the key to pain associated with CNS blood vessel dysfunction? This article reviews recent findings on the important physiological functions of CNS pericytes and highlights how these neurovascular functions could be linked to pain states.

AB - Central nervous system (CNS) pericytes regulate critical functions of the neurovascular unit in health and disease. CNS pericytes are an attractive pharmacological target for their position within the neurovasculature and for their role in neuroinflammation. Whether the function of CNS pericytes also affects pain states and nociceptive mechanisms is currently not understood. Could it be that pericytes hold the key to pain associated with CNS blood vessel dysfunction? This article reviews recent findings on the important physiological functions of CNS pericytes and highlights how these neurovascular functions could be linked to pain states.

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KW - Pain

KW - Pericytes

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M3 - Review article (Academic Journal)

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SN - 2046-1402

VL - 7

JO - F1000Research

JF - F1000Research

M1 - 341

ER -

The physiological functions of central nervous system pericytes and a potential role in pain

Abstract

Bibliographical note

Keywords

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