The potential for quality assurance systems to save costs and lives: the case of early infant diagnosis of HIV

Fern Terris-Prestholt*, D Boeras, Jason Ong*, Sergio Torres-Rueda, N Cassim, M.A.S. Mbengue, S Mboup, M Mwau, E Munemo, W Nyegenye, C. O. Odhiambo, P Dabula, P Sandstrom, M Sarr, R Simbi, W Stevens, J. Tucker, Peter T Vickerman, A Ciaranello, Rosanna W Peeling

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Objectives
Scaling up of point‐of‐care testing (POCT) for early infant diagnosis of HIV (EID) could reduce the large gap in infant testing. However, suboptimal POCT EID could have limited impact and potentially high avoidable costs. This study models the cost‐effectiveness of a quality assurance system to address testing performance and screening interruptions, due to e.g. supply stockouts, in Kenya, Senegal, South Africa, Uganda, Zimbabwe, with varying HIV epidemics and different health systems.

Methods
We modelled a quality assurance system‐raised EID quality from suboptimal levels: i.e. from misdiagnosis rates of 5%, 10% and 20% and EID testing interruptions in months, to uninterrupted optimal performance (98.5% sensitivity, 99.9% specificity). For each country, we estimated the 1‐year impact and cost‐effectiveness (US$/DALY averted) of improved scenarios in averting missed HIV infections and unneeded HIV treatment costs for false positive diagnoses.

Results
The modelled 1‐year costs of a national POCT quality assurance system range from US$ 69,359 in South Africa to US$ 334,341 in Zimbabwe. At the country‐level, quality assurance systems could potentially avert between 36 and 711 missed infections (i.e. false negatives) per year and unneeded treatment costs between US$ 5,808 and US$ 739,030.

Conclusions
The model estimates adding effective quality assurance systems is cost‐saving in four of the five countries within the first year. Starting EQA requires an initial investment but will provide a positive return on investment within five years by averting the costs of misdiagnoses and would be even more efficient if implemented across multiple applications of POCT.
Original languageEnglish
Pages (from-to)1235-1245
Number of pages11
JournalTropical Medicine and International Health
Volume25
Issue number10
DOIs
Publication statusPublished - 26 Aug 2020

Keywords

  • HIV
  • cost‐effectiveness
  • quality improvement programme
  • early infant diagnosis point‐of‐care testingearly infant diagnosis
  • point‐of‐care testing
  • VIH
  • rapport coȗt-efficacité
  • programme d'amélioration de la qualité
  • diagnostic précoce du nourrisson
  • dépistage au point des soins

Fingerprint Dive into the research topics of 'The potential for quality assurance systems to save costs and lives: the case of early infant diagnosis of HIV'. Together they form a unique fingerprint.

Cite this