The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function

Elizabeth Gray, Mark Ginty, Kevin Kemp, Neil Scolding, Alastair Wilkins

Research output: Contribution to journalArticle (Academic Journal)peer-review

55 Citations (Scopus)

Abstract

Inflammation is known to play a pivotal role in mediating neuronal damage and axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory mediators, nitric oxide and hydrogen peroxide are potent neurotoxic agents. Recent evidence has suggested that oligodendrocyte peroxisomes may play an important role in protecting neurons from inflammatory damage.
Original languageEnglish
Pages (from-to)63
JournalJournal of Neuroinflammation
Volume9
DOIs
Publication statusPublished - 2012

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