The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function

Elizabeth Gray; Mark Ginty; Kevin Kemp; Neil Scolding; Alastair Wilkins

doi:10.1186/1742-2094-9-63

The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function

Elizabeth Gray, Mark Ginty, Kevin Kemp, Neil Scolding, Alastair Wilkins

Research output: Contribution to journal › Article (Academic Journal) › peer-review

79 Citations (Scopus)

Abstract

Inflammation is known to play a pivotal role in mediating neuronal damage and axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory mediators, nitric oxide and hydrogen peroxide are potent neurotoxic agents. Recent evidence has suggested that oligodendrocyte peroxisomes may play an important role in protecting neurons from inflammatory damage.

Original language	English
Pages (from-to)	63
Journal	Journal of Neuroinflammation
Volume	9
DOIs	https://doi.org/10.1186/1742-2094-9-63
Publication status	Published - 2012

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title = "The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function",

abstract = "Inflammation is known to play a pivotal role in mediating neuronal damage and axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory mediators, nitric oxide and hydrogen peroxide are potent neurotoxic agents. Recent evidence has suggested that oligodendrocyte peroxisomes may play an important role in protecting neurons from inflammatory damage.",

author = "Elizabeth Gray and Mark Ginty and Kevin Kemp and Neil Scolding and Alastair Wilkins",

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T1 - The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function

AU - Gray, Elizabeth

AU - Ginty, Mark

AU - Kemp, Kevin

AU - Scolding, Neil

AU - Wilkins, Alastair

PY - 2012

Y1 - 2012

N2 - Inflammation is known to play a pivotal role in mediating neuronal damage and axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory mediators, nitric oxide and hydrogen peroxide are potent neurotoxic agents. Recent evidence has suggested that oligodendrocyte peroxisomes may play an important role in protecting neurons from inflammatory damage.

AB - Inflammation is known to play a pivotal role in mediating neuronal damage and axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory mediators, nitric oxide and hydrogen peroxide are potent neurotoxic agents. Recent evidence has suggested that oligodendrocyte peroxisomes may play an important role in protecting neurons from inflammatory damage.

U2 - 10.1186/1742-2094-9-63

DO - 10.1186/1742-2094-9-63

M3 - Article (Academic Journal)

C2 - 22480361

SN - 1742-2094

VL - 9

SP - 63

JO - Journal of Neuroinflammation

JF - Journal of Neuroinflammation

ER -

The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function

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