The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function

Elizabeth Gray; Mark Ginty; Kevin Kemp; Neil Scolding; Alastair Wilkins

doi:10.1186/1742-2094-9-63

The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function

Elizabeth Gray, Mark Ginty, Kevin Kemp, Neil Scolding, Alastair Wilkins

Research output: Contribution to journal › Article (Academic Journal) › peer-review

55 Citations (Scopus)

Abstract

Inflammation is known to play a pivotal role in mediating neuronal damage and axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory mediators, nitric oxide and hydrogen peroxide are potent neurotoxic agents. Recent evidence has suggested that oligodendrocyte peroxisomes may play an important role in protecting neurons from inflammatory damage.

Original language	English
Pages (from-to)	63
Journal	Journal of Neuroinflammation
Volume	9
DOIs	https://doi.org/10.1186/1742-2094-9-63
Publication status	Published - 2012

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title = "The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function",

abstract = "Inflammation is known to play a pivotal role in mediating neuronal damage and axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory mediators, nitric oxide and hydrogen peroxide are potent neurotoxic agents. Recent evidence has suggested that oligodendrocyte peroxisomes may play an important role in protecting neurons from inflammatory damage.",

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AU - Kemp, Kevin

AU - Scolding, Neil

AU - Wilkins, Alastair

PY - 2012

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AB - Inflammation is known to play a pivotal role in mediating neuronal damage and axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory mediators, nitric oxide and hydrogen peroxide are potent neurotoxic agents. Recent evidence has suggested that oligodendrocyte peroxisomes may play an important role in protecting neurons from inflammatory damage.

U2 - 10.1186/1742-2094-9-63

DO - 10.1186/1742-2094-9-63

M3 - Article (Academic Journal)

C2 - 22480361

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JO - Journal of Neuroinflammation

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