The prevalence of dementia subtypes in rural Tanzania

Stella-Maria Paddick, Anna Longdon, Aloyce Kisoli, William K Gray, Catherine L Dotchin, Ahmed Jusabani, Ahmed Iqbal, Julian Hughes, Andrew Teodorczuk, Paul Chaote, Richard W Walker

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Abstract

OBJECTIVES: The prevalence of dementia is predicted to increase rapidly in developing countries. Vascular risk factors may contribute to this rise. Our aim was to estimate the proportions of Alzheimer's disease (ADD) and vascular dementia (VAD) in a prevalent cohort of dementia cases in rural Tanzania.

DESIGN: A two-stage door-to-door dementia prevalence study.

SETTING: Hai district, Tanzania

PARTICIPANTS: In Phase I, the Community Screening Instrument for Dementia (CSI-D) was used to screen 1198 community-dwelling people for dementia. In Phase II, 168/184 (91.3%) of those with poor performance, 56/104 (53.8%) of those with intermediate performance and 72/910 (7.9%) of those with good performance on CSI-D were interviewed and diagnoses were made using the DSM-IV criteria.

MEASUREMENTS: For subtype diagnosis, DSM-IV dementia criteria plus NINCDS-ADRDA criteria were used for ADD and NINDS-AIREN criteria for VAD. Other dementias were diagnosed by international consensus criteria. Diagnoses were confirmed or excluded by computerised tomography where clinically appropriate.

RESULTS: Of 78 dementia cases, 38 (48.7%) were ADD and 32 (41.0%) were VAD. The crude prevalence of ADD was 3.7% (95% CI 2.5 to 4.9) and of VAD was 2.9% (95% CI 1.9 to 3.9). The age-adjusted prevalence was 3.0% (95% CI 1.8 to 4.2) for ADD and 2.6% (95% CI 1.6 to 3.6) for VAD. A previous diagnosis of diabetes mellitus was independently associated with greater odds of having VAD than ADD.

CONCLUSIONS: VAD accounted for a greater proportion of dementia cases than expected. Further investigation and treatment of risk factors is required in this setting.

Original languageEnglish
Pages (from-to)1613-22
Number of pages10
JournalAmerican Journal of Geriatric Psychiatry
Volume22
Issue number12
DOIs
Publication statusPublished - Dec 2014

Keywords

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Dementia, Vascular
  • Female
  • Humans
  • Male
  • Prevalence
  • Rural Population
  • Tanzania

Fingerprint Dive into the research topics of 'The prevalence of dementia subtypes in rural Tanzania'. Together they form a unique fingerprint.

  • Cite this

    Paddick, S-M., Longdon, A., Kisoli, A., Gray, W. K., Dotchin, C. L., Jusabani, A., Iqbal, A., Hughes, J., Teodorczuk, A., Chaote, P., & Walker, R. W. (2014). The prevalence of dementia subtypes in rural Tanzania. American Journal of Geriatric Psychiatry, 22(12), 1613-22. https://doi.org/10.1016/j.jagp.2014.02.004