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The prevalence of non-fatal overdose among people who inject drugs: a multi-stage systematic review and meta-analysis

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The prevalence of non-fatal overdose among people who inject drugs : a multi-stage systematic review and meta-analysis. / Colledge, Samantha; Peacock, Amy; Leung, Janni; Larney, Sarah; Grebely, Jason; Hickman, Matthew; Cunningham, Evan B; Trickey, Adam; Stone, Jack; Vickerman, Peter; Degenhardt, Louisa.

In: International Journal of Drug Policy, 24.07.2019.

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Colledge, S., Peacock, A., Leung, J., Larney, S., Grebely, J., Hickman, M., ... Degenhardt, L. (2019). The prevalence of non-fatal overdose among people who inject drugs: a multi-stage systematic review and meta-analysis. International Journal of Drug Policy. https://doi.org/10.1016/j.drugpo.2019.07.030

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Colledge, Samantha ; Peacock, Amy ; Leung, Janni ; Larney, Sarah ; Grebely, Jason ; Hickman, Matthew ; Cunningham, Evan B ; Trickey, Adam ; Stone, Jack ; Vickerman, Peter ; Degenhardt, Louisa. / The prevalence of non-fatal overdose among people who inject drugs : a multi-stage systematic review and meta-analysis. In: International Journal of Drug Policy. 2019.

Bibtex

@article{55f0a7f8524247f4ba085c4e74f85629,
title = "The prevalence of non-fatal overdose among people who inject drugs: a multi-stage systematic review and meta-analysis",
abstract = "Background: People who inject drugs (PWID) are at an elevated risk of fatal overdose in the first year after experiencing a non-fatal event. Such non-fatal events may also result in overdose-related sequelae, ranging from physical injury to paralysis. Given variation in drug markets and treatment availability across countries and regions, we may see similar variations in non-fatal overdose prevalence. Monitoring non-fatal overdose prevalence among PWID is essential for informing treatment intervention efforts, and thus our review aims to estimate the global, regional, and national prevalence of non-fatal overdose, and determine characteristics associated with experiencing such an event.Methods: We conducted a systematic review and meta-analyses to estimate country, regional, and global estimates of recent and lifetime non-fatal overdose prevalence among PWID. Using meta-regression analyses we also determined associations between sample characteristics and non-fatal overdose prevalence.Results: An estimated 3.2 (1.8-5.2) million PWID have experienced at least one overdose in the previous year. Among PWID, 20.5{\%} (15.0-26.1{\%}) and 41.5{\%} (34.6-48.4{\%}) had experienced a non-fatal event in the previous 12 months and lifetime respectively. Frequent injecting was strongly associated with PWID reporting recent and lifetime non-fatal overdose. Estimates of recent non-fatal overdose were particularly high in Asia and North America. Conclusion: Around one in five PWID are at an elevated risk of fatally overdosing every year, however there is substantial geographical variation. In countries with higher rates of non-fatal overdose there is need to introduce or mainstream overdose prevention strategies such as opioid agonist treatment and naloxone administration training programs.",
keywords = "drug-related mortality, injecting behavior, population size, opioid overdose, people who inject drugs, non-fatal overdose",
author = "Samantha Colledge and Amy Peacock and Janni Leung and Sarah Larney and Jason Grebely and Matthew Hickman and Cunningham, {Evan B} and Adam Trickey and Jack Stone and Peter Vickerman and Louisa Degenhardt",
year = "2019",
month = "7",
day = "24",
doi = "10.1016/j.drugpo.2019.07.030",
language = "English",
journal = "International Journal of Drug Policy",
issn = "0955-3959",
publisher = "Elsevier",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - The prevalence of non-fatal overdose among people who inject drugs

T2 - a multi-stage systematic review and meta-analysis

AU - Colledge, Samantha

AU - Peacock, Amy

AU - Leung, Janni

AU - Larney, Sarah

AU - Grebely, Jason

AU - Hickman, Matthew

AU - Cunningham, Evan B

AU - Trickey, Adam

AU - Stone, Jack

AU - Vickerman, Peter

AU - Degenhardt, Louisa

PY - 2019/7/24

Y1 - 2019/7/24

N2 - Background: People who inject drugs (PWID) are at an elevated risk of fatal overdose in the first year after experiencing a non-fatal event. Such non-fatal events may also result in overdose-related sequelae, ranging from physical injury to paralysis. Given variation in drug markets and treatment availability across countries and regions, we may see similar variations in non-fatal overdose prevalence. Monitoring non-fatal overdose prevalence among PWID is essential for informing treatment intervention efforts, and thus our review aims to estimate the global, regional, and national prevalence of non-fatal overdose, and determine characteristics associated with experiencing such an event.Methods: We conducted a systematic review and meta-analyses to estimate country, regional, and global estimates of recent and lifetime non-fatal overdose prevalence among PWID. Using meta-regression analyses we also determined associations between sample characteristics and non-fatal overdose prevalence.Results: An estimated 3.2 (1.8-5.2) million PWID have experienced at least one overdose in the previous year. Among PWID, 20.5% (15.0-26.1%) and 41.5% (34.6-48.4%) had experienced a non-fatal event in the previous 12 months and lifetime respectively. Frequent injecting was strongly associated with PWID reporting recent and lifetime non-fatal overdose. Estimates of recent non-fatal overdose were particularly high in Asia and North America. Conclusion: Around one in five PWID are at an elevated risk of fatally overdosing every year, however there is substantial geographical variation. In countries with higher rates of non-fatal overdose there is need to introduce or mainstream overdose prevention strategies such as opioid agonist treatment and naloxone administration training programs.

AB - Background: People who inject drugs (PWID) are at an elevated risk of fatal overdose in the first year after experiencing a non-fatal event. Such non-fatal events may also result in overdose-related sequelae, ranging from physical injury to paralysis. Given variation in drug markets and treatment availability across countries and regions, we may see similar variations in non-fatal overdose prevalence. Monitoring non-fatal overdose prevalence among PWID is essential for informing treatment intervention efforts, and thus our review aims to estimate the global, regional, and national prevalence of non-fatal overdose, and determine characteristics associated with experiencing such an event.Methods: We conducted a systematic review and meta-analyses to estimate country, regional, and global estimates of recent and lifetime non-fatal overdose prevalence among PWID. Using meta-regression analyses we also determined associations between sample characteristics and non-fatal overdose prevalence.Results: An estimated 3.2 (1.8-5.2) million PWID have experienced at least one overdose in the previous year. Among PWID, 20.5% (15.0-26.1%) and 41.5% (34.6-48.4%) had experienced a non-fatal event in the previous 12 months and lifetime respectively. Frequent injecting was strongly associated with PWID reporting recent and lifetime non-fatal overdose. Estimates of recent non-fatal overdose were particularly high in Asia and North America. Conclusion: Around one in five PWID are at an elevated risk of fatally overdosing every year, however there is substantial geographical variation. In countries with higher rates of non-fatal overdose there is need to introduce or mainstream overdose prevention strategies such as opioid agonist treatment and naloxone administration training programs.

KW - drug-related mortality

KW - injecting behavior

KW - population size

KW - opioid overdose

KW - people who inject drugs

KW - non-fatal overdose

U2 - 10.1016/j.drugpo.2019.07.030

DO - 10.1016/j.drugpo.2019.07.030

M3 - Article

JO - International Journal of Drug Policy

JF - International Journal of Drug Policy

SN - 0955-3959

ER -