The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation

Morteza Mahmoudi*, Marco P. Monopoli, Meisam Rezaei, Iseult Lynch, Filippo Bertoli, Jennifer J. Mcmanus, Kenneth A. Dawson

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Abstract

Put your coat on: It is well recognized that the surfaces of nanomaterials in biological media are covered by various biomolecules (e.g., proteins). A) The protein corona creates a shell over different nanomaterials, regardless of their physicochemical properties (e.g., composition and shape), resulting in reduced levels of amyloid beta fibril formation. B) Pristine nanomaterials might have acceleratory effects on the fibrillation of amyloid beta.

Original languageEnglish
Pages (from-to)568-572
Number of pages5
JournalChemBioChem
Volume14
Issue number5
DOIs
Publication statusPublished - 1 Mar 2013

Keywords

  • Fibrillation
  • Inhibitory effect
  • Nanomaterials
  • Physicochemical properties
  • Protein corona

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