The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation

Morteza Mahmoudi; Marco P. Monopoli; Meisam Rezaei; Iseult Lynch; Filippo Bertoli; Jennifer J. Mcmanus; Kenneth A. Dawson

doi:10.1002/cbic.201300007

The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation

Morteza Mahmoudi^*, Marco P. Monopoli, Meisam Rezaei, Iseult Lynch, Filippo Bertoli, Jennifer J. Mcmanus, Kenneth A. Dawson

^*Corresponding author for this work

School of Physics

Research output: Contribution to journal › Article (Academic Journal) › peer-review

54 Citations (Scopus)

Abstract

Put your coat on: It is well recognized that the surfaces of nanomaterials in biological media are covered by various biomolecules (e.g., proteins). A) The protein corona creates a shell over different nanomaterials, regardless of their physicochemical properties (e.g., composition and shape), resulting in reduced levels of amyloid beta fibril formation. B) Pristine nanomaterials might have acceleratory effects on the fibrillation of amyloid beta.

Original language	English
Pages (from-to)	568-572
Number of pages	5
Journal	ChemBioChem
Volume	14
Issue number	5
DOIs	https://doi.org/10.1002/cbic.201300007
Publication status	Published - 1 Mar 2013

Keywords

Fibrillation
Inhibitory effect
Nanomaterials
Physicochemical properties
Protein corona

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title = "The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation",

abstract = "Put your coat on: It is well recognized that the surfaces of nanomaterials in biological media are covered by various biomolecules (e.g., proteins). A) The protein corona creates a shell over different nanomaterials, regardless of their physicochemical properties (e.g., composition and shape), resulting in reduced levels of amyloid beta fibril formation. B) Pristine nanomaterials might have acceleratory effects on the fibrillation of amyloid beta.",

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T1 - The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation

AU - Mahmoudi, Morteza

AU - Monopoli, Marco P.

AU - Rezaei, Meisam

AU - Lynch, Iseult

AU - Bertoli, Filippo

AU - Mcmanus, Jennifer J.

AU - Dawson, Kenneth A.

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Put your coat on: It is well recognized that the surfaces of nanomaterials in biological media are covered by various biomolecules (e.g., proteins). A) The protein corona creates a shell over different nanomaterials, regardless of their physicochemical properties (e.g., composition and shape), resulting in reduced levels of amyloid beta fibril formation. B) Pristine nanomaterials might have acceleratory effects on the fibrillation of amyloid beta.

AB - Put your coat on: It is well recognized that the surfaces of nanomaterials in biological media are covered by various biomolecules (e.g., proteins). A) The protein corona creates a shell over different nanomaterials, regardless of their physicochemical properties (e.g., composition and shape), resulting in reduced levels of amyloid beta fibril formation. B) Pristine nanomaterials might have acceleratory effects on the fibrillation of amyloid beta.

KW - Fibrillation

KW - Inhibitory effect

KW - Nanomaterials

KW - Physicochemical properties

KW - Protein corona

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U2 - 10.1002/cbic.201300007

DO - 10.1002/cbic.201300007

M3 - Article (Academic Journal)

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AN - SCOPUS:84874989371

SN - 1439-4227

VL - 14

SP - 568

EP - 572

JO - ChemBioChem

JF - ChemBioChem

IS - 5

ER -

The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation

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Keywords

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