The providential randomisation of genotypes

Jean-Baptiste Pingault; Pasco Fearon; Essi Viding; Neil Davies; Marcus R Munafò; George Davey Smith

doi:10.1017/S0140525X2200214X

The providential randomisation of genotypes

Jean-Baptiste Pingault, Pasco Fearon, Essi Viding, Neil Davies, Marcus R Munafò, George Davey Smith

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Abstract

When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.

Original language	English
Article number	e197
Journal	The Behavioral and brain sciences
Volume	46
DOIs	https://doi.org/10.1017/S0140525X2200214X
Publication status	Published - 11 Sept 2023

Bibliographical note

Publisher Copyright:
Copyright © The Author(s), 2023. Published by Cambridge University Press.

Research Groups and Themes

Bristol Population Health Science Institute
TARG

Keywords

Humans
Genotype
Random Allocation
Genetics, Behavioral

Access to Document

10.1017/S0140525X2200214X

Full-text PDF (accepted manuscript)
This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Cambridge University Press at https://doi.org/10.1017/S0140525X2200214X. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 152 KBLicence: CC BY-NC-ND

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Persistent link

IEU: MRC Integrative Epidemiology Unit Quinquennial renewal
Gaunt, L. F. (Principal Investigator) & Davey Smith, G. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research

Cite this

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abstract = "When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.",

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AU - Pingault, Jean-Baptiste

AU - Fearon, Pasco

AU - Viding, Essi

AU - Davies, Neil

AU - Munafò, Marcus R

AU - Davey Smith, George

PY - 2023/9/11

Y1 - 2023/9/11

N2 - When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.

AB - When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.

KW - Humans

KW - Genotype

KW - Random Allocation

KW - Genetics, Behavioral

U2 - 10.1017/S0140525X2200214X

DO - 10.1017/S0140525X2200214X

M3 - Article (Academic Journal)

C2 - 37694914

SN - 0140-525X

VL - 46

JO - The Behavioral and brain sciences

JF - The Behavioral and brain sciences

M1 - e197

ER -

The providential randomisation of genotypes

Abstract

Bibliographical note

Research Groups and Themes

Keywords

Access to Document

Handle.net

Fingerprint

Projects

IEU: MRC Integrative Epidemiology Unit Quinquennial renewal

Cite this