@inbook{1f8bad07f68e411487e6c2f570af187b,
title = "The regulation of organelle function through changes in their volume",
abstract = "Although a search of the literature provides evidence for morphological changes in many subcellular organelles in response to a variety of stimuli, the only subcellular organelle whose volume regulation has been studied in detail is the mitochondrion. For this organelle there is evidence for an important physiological role for volume regulation, thus this chapter will focus on the regulation of mitochondrial volume and its metabolic consequences. I will first review the mechanisms involved in volume homeostasis and secondly describe how, in the liver at least, mitochondrial volume may also be regulated by extrinsic factors such as hormones. I will then describe how such volume regulation may have profound effects on mitochondrial metabolism that are important for the overall effects of the hormones on liver metabolism. I will suggest that similar effects may follow changes in cellular volume such as those described by Haussinger (this Vol.). The evidence for changes in the mitochondrial volume induced by physiological stimuli in other tissues will also be reviewed briefly.",
author = "Halestrap, {Andrew P}",
year = "1993",
doi = "10.1007/978-3-642-77124-8_9",
language = "English",
isbn = "9783642771262",
series = "Advances in Comparative and Environmental Physiology",
publisher = "Springer Berlin Heidelberg",
pages = "279--307",
editor = "Florian Lang and Dieter Haussinger",
booktitle = "Advances in Comparative and Environmental Physiology",
address = "Germany",
}