TY - JOUR
T1 - The relation between stressful life events and breast cancer
T2 - a systematic review and meta-analysis of cohort studies
AU - Bahri, Narjes
AU - Fathi Najafi, Tahereh
AU - Homaei Shandiz, Fatemeh
AU - Tohidinik, Hamid Reza
AU - Khajavi, Abdoljavad
N1 - Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/7/15
Y1 - 2019/7/15
N2 - Purpose: Breast cancer is the most common cancer among women with high rate of mortality. This systematic review and meta-analysis was conducted to investigate the relation between stressful life events and breast cancer. Methods: We searched PubMed, Scopus, ScienceDirect, and Google scholar databases from their inception until June 2018. The keywords and phrases we used in the search were (life events AND stress AND breast cancer OR neoplasm) to identify potentially relevant cohort studies that reported relative risk estimates and confidence intervals of this association. Pooled Risk ratio and 95% confidence intervals (CIs) were calculated using random effects model. Results: Out of 168 potentially relevant publications, 11 documents met the inclusion criteria. The results showed that history of stressful life events slightly increases the risk of breast cancer [pooled Risk Ratio: 1.11 (95% CI 1.03 to 1.19)]. Conclusions: History of stressful life events could be associated with a moderate increase in the risk of breast cancer. We advise that receiving psychological and counseling services after occurrence of stressful life events of women should be taken seriously.
AB - Purpose: Breast cancer is the most common cancer among women with high rate of mortality. This systematic review and meta-analysis was conducted to investigate the relation between stressful life events and breast cancer. Methods: We searched PubMed, Scopus, ScienceDirect, and Google scholar databases from their inception until June 2018. The keywords and phrases we used in the search were (life events AND stress AND breast cancer OR neoplasm) to identify potentially relevant cohort studies that reported relative risk estimates and confidence intervals of this association. Pooled Risk ratio and 95% confidence intervals (CIs) were calculated using random effects model. Results: Out of 168 potentially relevant publications, 11 documents met the inclusion criteria. The results showed that history of stressful life events slightly increases the risk of breast cancer [pooled Risk Ratio: 1.11 (95% CI 1.03 to 1.19)]. Conclusions: History of stressful life events could be associated with a moderate increase in the risk of breast cancer. We advise that receiving psychological and counseling services after occurrence of stressful life events of women should be taken seriously.
KW - Breast cancer
KW - Life events
KW - Neoplasm
KW - Psychological distress
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=85064659157&partnerID=8YFLogxK
U2 - 10.1007/s10549-019-05231-x
DO - 10.1007/s10549-019-05231-x
M3 - Review article (Academic Journal)
C2 - 31004298
AN - SCOPUS:85064659157
SN - 0167-6806
VL - 176
SP - 53
EP - 61
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 1
ER -
