The relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system

Derek D Satre*, Tory Levine-Hall, Stacey A Sterling, Kelly Young-Wolff, Jennifer O Lam, Stacey Alexeeff, Carlo Hojilla, Andrew Williams, Amy C Justice, Jonathan A C Sterne, Matthias Cavassini, Kendall J Bryant, Emily C Williams, Michael A Horberg, Paul Volberding, Constance Weisner, Michael J Silverberg

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Introduction

Smoking tobacco and unhealthy alcohol use may negatively influence HIV care continuum outcomes but have not been examined in combination.

Methods

Participants were people with HIV (PWH) in Kaiser Permanente Northern California. Predictors included smoking status and unhealthy alcohol use (exceeding daily and/or weekly limits) reported by patients during primary care screening (index date). Outcomes were based on not achieving the following steps in the care continuum: linkage to HIV care (≥1 visit within 90 days of newly identified HIV diagnosis), retention (2+ in-person visits, 60+ days apart) and HIV RNA control (<75 copies/mL). Adjusted odds ratios (ORs) were obtained from separate logistic regression models for each outcome associated with smoking and unhealthy alcohol use independently and combined.

Results

The overall sample (N = 8958) had a mean age of 48.0 years; was 91.3 % male; 54.0 % white, 17.6 % Latino, 15.1 % black, and 9.6 % other race/ethnicity. Smoking was associated with higher odds of not being linked to HIV care (OR = 1.60 [95 % CI 1.03−2.48]), not retained (OR = 1.30 [95 % CI 1.13−1.50]), and HIV RNA not in control (OR = 1.91 [95 % CI 1.60−2.27]). Alcohol measures were not independently associated with outcomes. The combination of unhealthy alcohol use and smoking (versus neither) was associated with higher odds of not being linked to care (OR = 2.83 [95 % CI 1.40−5.71]), although the interaction did not reach significance (p = 0.18).

Conclusions

In this large sample of PWH in an integrated health care system, smoking, both independently and in combination with unhealthy alcohol use, was associated with worse HIV care continuum outcomes.


Original languageEnglish
Article number108481
Number of pages9
JournalDrug and Alcohol Dependence
Volume219
Early online date8 Jan 2021
DOIs
Publication statusPublished - 1 Feb 2021

Bibliographical note

Funding Information:
Funding was provided by the National Institute on Alcohol Abuse and Alcoholism , U01AA026230 , K24AA025703 . The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication

Publisher Copyright:
© 2020 Elsevier B.V.

Keywords

  • smoking
  • alcohol
  • primary care
  • integrated health care
  • HIV care continuum
  • viral control

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