The ReSPonD trial - rivastigmine to stabilise gait in Parkinson's disease a phase II, randomised, double blind, placebo controlled trial to evaluate the effect of rivastigmine on gait in patients with Parkinson's disease who have fallen

Emily J Henderson; Stephen R Lord; Jacqueline Ct Close; Andrew D Lawrence; Alan Whone; Yoav Ben-Shlomo

doi:10.1186/1471-2377-13-188

The ReSPonD trial - rivastigmine to stabilise gait in Parkinson's disease a phase II, randomised, double blind, placebo controlled trial to evaluate the effect of rivastigmine on gait in patients with Parkinson's disease who have fallen

Emily J Henderson, Stephen R Lord, Jacqueline Ct Close, Andrew D Lawrence, Alan Whone, Yoav Ben-Shlomo

Research output: Contribution to journal › Article (Academic Journal) › peer-review

24 Citations (Scopus)

Abstract

Gait impairment is common in people with Parkinson's disease. There is a lack of effective interventions to target this debilitating complication and therefore a need to identify new therapeutic options. An underlying cholinergic deficit contributes to both the gait and cognitive dysfunction seen in Parkinson's disease. The combined impact of both impairments can be assessed in gait tasks performed with concomitant cognitive tasks. The aim of this trial is to evaluate the impact of a cholinesterase inhibitor on cognitive function and gait performance in people with established Parkinson's disease.

Original language	English
Pages (from-to)	188
Journal	BMC Neurology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/1471-2377-13-188
Publication status	Published - 2013

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Henderson, E. J., Lord, S. R., Close, J. C., Lawrence, A. D., Whone, A., & Ben-Shlomo, Y. (2013). The ReSPonD trial - rivastigmine to stabilise gait in Parkinson's disease a phase II, randomised, double blind, placebo controlled trial to evaluate the effect of rivastigmine on gait in patients with Parkinson's disease who have fallen. BMC Neurology, 13(1), 188. https://doi.org/10.1186/1471-2377-13-188

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abstract = "Gait impairment is common in people with Parkinson's disease. There is a lack of effective interventions to target this debilitating complication and therefore a need to identify new therapeutic options. An underlying cholinergic deficit contributes to both the gait and cognitive dysfunction seen in Parkinson's disease. The combined impact of both impairments can be assessed in gait tasks performed with concomitant cognitive tasks. The aim of this trial is to evaluate the impact of a cholinesterase inhibitor on cognitive function and gait performance in people with established Parkinson's disease.",

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Henderson, EJ, Lord, SR, Close, JC, Lawrence, AD, Whone, A & Ben-Shlomo, Y 2013, 'The ReSPonD trial - rivastigmine to stabilise gait in Parkinson's disease a phase II, randomised, double blind, placebo controlled trial to evaluate the effect of rivastigmine on gait in patients with Parkinson's disease who have fallen', BMC Neurology, vol. 13, no. 1, pp. 188. https://doi.org/10.1186/1471-2377-13-188

The ReSPonD trial - rivastigmine to stabilise gait in Parkinson's disease a phase II, randomised, double blind, placebo controlled trial to evaluate the effect of rivastigmine on gait in patients with Parkinson's disease who have fallen. / Henderson, Emily J; Lord, Stephen R; Close, Jacqueline Ct et al.

In: BMC Neurology, Vol. 13, No. 1, 2013, p. 188.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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AB - Gait impairment is common in people with Parkinson's disease. There is a lack of effective interventions to target this debilitating complication and therefore a need to identify new therapeutic options. An underlying cholinergic deficit contributes to both the gait and cognitive dysfunction seen in Parkinson's disease. The combined impact of both impairments can be assessed in gait tasks performed with concomitant cognitive tasks. The aim of this trial is to evaluate the impact of a cholinesterase inhibitor on cognitive function and gait performance in people with established Parkinson's disease.

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Henderson EJ, Lord SR, Close JC, Lawrence AD, Whone A , Ben-Shlomo Y. The ReSPonD trial - rivastigmine to stabilise gait in Parkinson's disease a phase II, randomised, double blind, placebo controlled trial to evaluate the effect of rivastigmine on gait in patients with Parkinson's disease who have fallen. BMC Neurology. 2013;13(1):188. https://doi.org/10.1186/1471-2377-13-188