Abstract
RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review.
Original language | English |
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Pages (from-to) | 1-10 |
Number of pages | 10 |
Journal | Small GTPases |
Early online date | 22 Nov 2016 |
DOIs | |
Publication status | E-pub ahead of print - 22 Nov 2016 |
Keywords
- Journal Article