The RhoB small GTPase in physiology and disease

Francisco M Vega, Anne J Ridley

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalSmall GTPases
Early online date22 Nov 2016
DOIs
Publication statusE-pub ahead of print - 22 Nov 2016

Keywords

  • Journal Article

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