The RhoB small GTPase in physiology and disease

Francisco M Vega; Anne J Ridley

doi:10.1080/21541248.2016.1253528

The RhoB small GTPase in physiology and disease

Francisco M Vega
, Anne J Ridley

Research output: Contribution to journal › Article (Academic Journal) › peer-review

69 Citations (Scopus)

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Abstract

RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Small GTPases
Early online date	22 Nov 2016
DOIs	https://doi.org/10.1080/21541248.2016.1253528
Publication status	E-pub ahead of print - 22 Nov 2016

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Journal Article

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10.1080/21541248.2016.1253528Licence: CC BY-NC-ND

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abstract = "RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review.",

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AB - RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review.

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JF - Small GTPases

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The RhoB small GTPase in physiology and disease

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