Projects per year
Abstract
With its identification as a proto-oncogene in chronic lymphocytic leukaemia and central role in regulating NF-κB signalling, it is perhaps not surprising that there have been an increasing number of studies in recent years investigating the role of BCL-3 (B-Cell Chronic Lymphocytic Leukaemia/Lymphoma-3) in a wide range of human cancers. Importantly, this work has begun to shed light on our mechanistic understanding of the function of BCL-3 in tumour promotion and progression. Here, we summarize the current understanding of BCL-3 function in relation to the characteristics or traits associated with tumourigenesis, termed ‘Hallmarks of Cancer’. With the focus on colorectal cancer, a major cause of cancer related mortality in the UK, we describe the evidence that potentially explains why increased BCL-3 expression is associated with poor prognosis in colorectal cancer. As well as promoting tumour cell proliferation, survival, invasion and metastasis, a key emerging function of this proto-oncogene is the regulation of the tumour response to inflammation. We suggest that BCL-3 represents an exciting new route for targeting the Hallmarks of Cancer; in particular by limiting the impact of the enabling hallmarks of tumour promoting inflammation and cell plasticity. As BCL-3 has been reported to promote the stem-like potential of cancer cells, we suggest that targeting BCL-3 could increase the tumour response to conventional treatment, reduce the chance of relapse and hence improve the prognosis for cancer patients.
Original language | English |
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Article number | bgaa003 |
Number of pages | 8 |
Journal | Carcinogenesis |
Early online date | 13 Jan 2020 |
DOIs | |
Publication status | E-pub ahead of print - 13 Jan 2020 |
Keywords
- cancer
- colorectal cancer
- lymphoma
- bcl3 protein
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Dive into the research topics of 'The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer: implications for the treatment of colorectal carcinogenesis'. Together they form a unique fingerprint.Projects
- 1 Finished
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Investigating the function of the BCL-3/Beta-canetin complex in promoting intestinal tumorigenesis and acquisition of therapeutic resistance
Williams, A. C. (Principal Investigator)
1/07/18 → 30/09/21
Project: Research
Student theses
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Exploring the role of BCL-3 in colorectal cancer cell therapeutic resistance
Parker, C. T. (Author), Martin, P. (Supervisor), Cullen, P. (Supervisor) & Williams, A. (Supervisor), 24 Jun 2021Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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