TY - JOUR
T1 - The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus
AU - Bortolotto, Zuner
AU - Collingridge, Graham
AU - Kang, HyeWon Heather
PY - 2018/11/22
Y1 - 2018/11/22
N2 - Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic plasticity at these synapses. Here, we review this literature with a focus on recent evidence that CP-AMPARs are critical for the induction of the protein kinase A (PKA)- and protein synthesis-dependent component of LTP.
AB - Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic plasticity at these synapses. Here, we review this literature with a focus on recent evidence that CP-AMPARs are critical for the induction of the protein kinase A (PKA)- and protein synthesis-dependent component of LTP.
KW - NMDA receptor
KW - long-term potentiation
KW - hippocampus;
KW - calcium-permeable AMPA receptor
KW - PKA
U2 - 10.3389/fnsyn.2018.00042
DO - 10.3389/fnsyn.2018.00042
M3 - Article (Academic Journal)
C2 - 30524263
SN - 1663-3563
VL - 10
JO - Frontiers in Synaptic Neuroscience
JF - Frontiers in Synaptic Neuroscience
M1 - 42
ER -