The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus

Zuner Bortolotto, Graham Collingridge, HyeWon Heather Kang

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic plasticity at these synapses. Here, we review this literature with a focus on recent evidence that CP-AMPARs are critical for the induction of the protein kinase A (PKA)- and protein synthesis-dependent component of LTP.
Original languageEnglish
Article number42
Number of pages11
JournalFrontiers in Synaptic Neuroscience
Volume10
DOIs
Publication statusPublished - 22 Nov 2018

Keywords

  • NMDA receptor
  • long-term potentiation
  • hippocampus;
  • calcium-permeable AMPA receptor
  • PKA

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