The Role of Chemokines, Cytokines and Adhesion Molecules in Stem Cell Trafficking and Homing

Y Cui, PR Madeddu

Research output: Contribution to journalArticle (Academic Journal)peer-review

21 Citations (Scopus)

Abstract

Although definition and mechanistic understanding of pro-angiogenic progenitor cells remains unsatisfactory, general agreement highlights their role in regenerative process following tissue injury and ischemia. Furthermore, stem-cell based therapy represents a hot topic of cardiovascular medicine. Recent studies provide new insights on the signalling pathways that modulate stem/progenitor cell mobilization from bone marrow, homing to ischemic area and participation in vascular remodelling and tissue healing. This review focuses on current knowledge and emerging concepts on stem cell/progenitor cell trafficking in relation to changes in surrounding environment and epigenetic modifications caused by risk factors and comorbidities.
Translated title of the contributionThe Role of Chemokines, Cytokines and Adhesion Molecules in Stem Cell Trafficking and Homing
Original languageEnglish
Pages (from-to)3271 - 3279
Number of pages9
JournalCurrent Pharmaceutical Design
Volume17(30)
Publication statusPublished - Oct 2011

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