Abstract
Although definition and mechanistic understanding of pro-angiogenic progenitor cells remains unsatisfactory, general agreement highlights their role in regenerative process following tissue injury and ischemia. Furthermore, stem-cell based therapy represents a hot topic of cardiovascular medicine. Recent studies provide new insights on the signalling pathways that modulate stem/progenitor cell mobilization from bone marrow, homing to ischemic area and participation in vascular remodelling and tissue healing. This review focuses on current knowledge and emerging concepts on stem cell/progenitor cell trafficking in relation to changes in surrounding environment and epigenetic modifications caused by risk factors and comorbidities.
| Translated title of the contribution | The Role of Chemokines, Cytokines and Adhesion Molecules in Stem Cell Trafficking and Homing |
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| Original language | English |
| Pages (from-to) | 3271 - 3279 |
| Number of pages | 9 |
| Journal | Current Pharmaceutical Design |
| Volume | 17(30) |
| Publication status | Published - Oct 2011 |