The role of JAK-STAT signaling within the CNS

Celine S Nicolas; Mascia Amici; Zuner A Bortolotto; Andrew Doherty; Zsolt Csaba; Assia Fafouri; Pascal Dournaud; Pierre Gressens; Graham L Collingridge; Stephane Peineau

doi:10.4161/jkst.22925

The role of JAK-STAT signaling within the CNS

Celine S Nicolas, Mascia Amici, Zuner A Bortolotto, Andrew Doherty, Zsolt Csaba, Assia Fafouri, Pascal Dournaud, Pierre Gressens, Graham L Collingridge, Stephane Peineau

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Abstract

JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of gene expression. Primarily identified as functioning in hematopoietic cells, its role has been found critical in all cell types, including neurons. This review will focus on JAK-STAT functions in the mature central nervous system. Our recent research suggests the intriguing possibility of a non-nuclear role of STAT3 during synaptic plasticity. Dysregulation of the JAK-STAT pathway in inflammation, cancer and neurodegenerative diseases positions it at the heart of most brain disorders, highlighting the importance to understand how it can influence the fate and functions of brain cells.

Original language	English
Article number	e22925
Number of pages	10
Journal	JAK-STAT
Volume	2
Issue number	1
Early online date	1 Jan 2013
DOIs	https://doi.org/10.4161/jkst.22925
Publication status	Published - Jan 2013

Keywords

synaptic plasticity
long term depression
JAK2
STAT3
inflammation
cancer
NMDA receptor
hormonal regulation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/jkst.22925

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MECHANISMS OF NMDA RECEPTOR DEPENDANT LTP AND LTD IN THE HIPPOCAMPUS
Collingridge, G. L. (Principal Investigator)
1/01/08 → 1/04/13
Project: Research

Cite this

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AU - Nicolas, Celine S

AU - Amici, Mascia

AU - Bortolotto, Zuner A

AU - Doherty, Andrew

AU - Csaba, Zsolt

AU - Fafouri, Assia

AU - Dournaud, Pascal

AU - Gressens, Pierre

AU - Collingridge, Graham L

AU - Peineau, Stephane

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KW - synaptic plasticity

KW - long term depression

KW - JAK2

KW - STAT3

KW - inflammation

KW - cancer

KW - NMDA receptor

KW - hormonal regulation

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The role of JAK-STAT signaling within the CNS

Abstract

Keywords

UN SDGs

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MECHANISMS OF NMDA RECEPTOR DEPENDANT LTP AND LTD IN THE HIPPOCAMPUS

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