The role of JAK-STAT signaling within the CNS

Celine S Nicolas, Mascia Amici, Zuner A Bortolotto, Andrew Doherty, Zsolt Csaba, Assia Fafouri, Pascal Dournaud, Pierre Gressens, Graham L Collingridge, Stephane Peineau

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Abstract

JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of gene expression. Primarily identified as functioning in hematopoietic cells, its role has been found critical in all cell types, including neurons. This review will focus on JAK-STAT functions in the mature central nervous system. Our recent research suggests the intriguing possibility of a non-nuclear role of STAT3 during synaptic plasticity. Dysregulation of the JAK-STAT pathway in inflammation, cancer and neurodegenerative diseases positions it at the heart of most brain disorders, highlighting the importance to understand how it can influence the fate and functions of brain cells.
Original languageEnglish
Article numbere22925
Number of pages10
JournalJAK-STAT
Volume2
Issue number1
Early online date1 Jan 2013
DOIs
Publication statusPublished - Jan 2013

Keywords

  • synaptic plasticity
  • long term depression
  • JAK2
  • STAT3
  • inflammation
  • cancer
  • NMDA receptor
  • hormonal regulation

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