Skip to content

The role of JAK-STAT signaling within the CNS

Research output: Contribution to journalArticle

Original languageEnglish
Article numbere22925
Number of pages10
Issue number1
Early online date1 Jan 2013
DateE-pub ahead of print - 1 Jan 2013
DatePublished (current) - Jan 2013


JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of gene expression. Primarily identified as functioning in hematopoietic cells, its role has been found critical in all cell types, including neurons. This review will focus on JAK-STAT functions in the mature central nervous system. Our recent research suggests the intriguing possibility of a non-nuclear role of STAT3 during synaptic plasticity. Dysregulation of the JAK-STAT pathway in inflammation, cancer and neurodegenerative diseases positions it at the heart of most brain disorders, highlighting the importance to understand how it can influence the fate and functions of brain cells.

    Research areas

  • synaptic plasticity, long term depression, JAK2, STAT3, inflammation, cancer, NMDA receptor, hormonal regulation

Download statistics

No data available




View research connections

Related faculties, schools or groups