The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

Jane W. Y. Ng, Laura M. Barrett, Andrew Wong, Diana Kuh, George Davey Smith, Caroline L. Relton*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

57 Citations (Scopus)

Abstract

Longitudinal cohort studies are ideal for investigating how epigenetic patterns change over time and relate to changing exposure patterns and the development of disease. We highlight the challenges and opportunities in this approach.

Original languageEnglish
Pages (from-to)246
Number of pages13
JournalGenome Biology
Volume13
Issue number6
DOIs
Publication statusPublished - 2012

Keywords

  • Epigenomics
  • DNA methylation
  • life course
  • longitudinal studies
  • GENE PROMOTER METHYLATION
  • POSTTRAUMATIC-STRESS-DISORDER
  • CARDIOVASCULAR-DISEASE RISK
  • LIFE-COURSE EPIDEMIOLOGY
  • GENOMIC DNA METHYLATION
  • TIME-COURSE DATA
  • CANCER-RISK
  • MENDELIAN RANDOMIZATION
  • COLORECTAL-CANCER
  • BIRTH COHORT

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