The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

Jane W. Y. Ng; Laura M. Barrett; Andrew Wong; Diana Kuh; George Davey Smith; Caroline L. Relton

doi:10.1186/gb-2012-13-6-246

The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

Jane W. Y. Ng, Laura M. Barrett, Andrew Wong, Diana Kuh, George Davey Smith, Caroline L. Relton^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

80 Citations (Scopus)

Abstract

Longitudinal cohort studies are ideal for investigating how epigenetic patterns change over time and relate to changing exposure patterns and the development of disease. We highlight the challenges and opportunities in this approach.

Original language	English
Pages (from-to)	246
Number of pages	13
Journal	Genome Biology
Volume	13
Issue number	6
DOIs	https://doi.org/10.1186/gb-2012-13-6-246
Publication status	Published - 2012

Keywords

Epigenomics
DNA methylation
life course
longitudinal studies
GENE PROMOTER METHYLATION
POSTTRAUMATIC-STRESS-DISORDER
CARDIOVASCULAR-DISEASE RISK
LIFE-COURSE EPIDEMIOLOGY
GENOMIC DNA METHYLATION
TIME-COURSE DATA
CANCER-RISK
MENDELIAN RANDOMIZATION
COLORECTAL-CANCER
BIRTH COHORT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{2159352afe434523bf9bbafe5343d47b,

title = "The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities",

abstract = "Longitudinal cohort studies are ideal for investigating how epigenetic patterns change over time and relate to changing exposure patterns and the development of disease. We highlight the challenges and opportunities in this approach.",

keywords = "Epigenomics, DNA methylation, life course, longitudinal studies, GENE PROMOTER METHYLATION, POSTTRAUMATIC-STRESS-DISORDER, CARDIOVASCULAR-DISEASE RISK, LIFE-COURSE EPIDEMIOLOGY, GENOMIC DNA METHYLATION, TIME-COURSE DATA, CANCER-RISK, MENDELIAN RANDOMIZATION, COLORECTAL-CANCER, BIRTH COHORT",

author = "Ng, {Jane W. Y.} and Barrett, {Laura M.} and Andrew Wong and Diana Kuh and Smith, {George Davey} and Relton, {Caroline L.}",

year = "2012",

doi = "10.1186/gb-2012-13-6-246",

language = "English",

volume = "13",

pages = "246",

journal = "Genome Biology",

issn = "1474-7596",

publisher = "BioMed Central",

number = "6",

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TY - JOUR

T1 - The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

AU - Ng, Jane W. Y.

AU - Barrett, Laura M.

AU - Wong, Andrew

AU - Kuh, Diana

AU - Smith, George Davey

AU - Relton, Caroline L.

PY - 2012

Y1 - 2012

N2 - Longitudinal cohort studies are ideal for investigating how epigenetic patterns change over time and relate to changing exposure patterns and the development of disease. We highlight the challenges and opportunities in this approach.

AB - Longitudinal cohort studies are ideal for investigating how epigenetic patterns change over time and relate to changing exposure patterns and the development of disease. We highlight the challenges and opportunities in this approach.

KW - Epigenomics

KW - DNA methylation

KW - life course

KW - longitudinal studies

KW - GENE PROMOTER METHYLATION

KW - POSTTRAUMATIC-STRESS-DISORDER

KW - CARDIOVASCULAR-DISEASE RISK

KW - LIFE-COURSE EPIDEMIOLOGY

KW - GENOMIC DNA METHYLATION

KW - TIME-COURSE DATA

KW - CANCER-RISK

KW - MENDELIAN RANDOMIZATION

KW - COLORECTAL-CANCER

KW - BIRTH COHORT

U2 - 10.1186/gb-2012-13-6-246

DO - 10.1186/gb-2012-13-6-246

M3 - Review article (Academic Journal)

C2 - 22747597

SN - 1474-7596

VL - 13

SP - 246

JO - Genome Biology

JF - Genome Biology

IS - 6

ER -

The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

Abstract

Keywords

UN SDGs

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