TY - JOUR
T1 - The Role of Mast Cells in Tuberculosis
T2 - Orchestrating Innate Immune Crosstalk?
AU - Garcia-Rodriguez, Karen M
AU - Goenka, Anu
AU - Alonso-Rasgado, Maria T
AU - Hernández-Pando, Rogelio
AU - Bulfone-Paus, Silvia
PY - 2017
Y1 - 2017
N2 - Tuberculosis causes more annual deaths globally than any other infectious disease. However, progress in developing novel vaccines, diagnostics, and therapies has been hampered by an incomplete understanding of the immune response to Mycobacterium tuberculosis (Mtb). While the role of many immune cells has been extensively explored, mast cells (MCs) have been relatively ignored. MCs are tissue resident cells involved in defense against bacterial infections playing an important role mediating immune cell crosstalk. This review discusses specific interactions between MCs and Mtb, their contribution to both immunity and disease pathogenesis, and explores their role in orchestrating other immune cells against infections.
AB - Tuberculosis causes more annual deaths globally than any other infectious disease. However, progress in developing novel vaccines, diagnostics, and therapies has been hampered by an incomplete understanding of the immune response to Mycobacterium tuberculosis (Mtb). While the role of many immune cells has been extensively explored, mast cells (MCs) have been relatively ignored. MCs are tissue resident cells involved in defense against bacterial infections playing an important role mediating immune cell crosstalk. This review discusses specific interactions between MCs and Mtb, their contribution to both immunity and disease pathogenesis, and explores their role in orchestrating other immune cells against infections.
U2 - 10.3389/fimmu.2017.01290
DO - 10.3389/fimmu.2017.01290
M3 - Review article (Academic Journal)
C2 - 29089945
SN - 1664-3224
VL - 8
SP - 1290
JO - Frontiers in Immunology
JF - Frontiers in Immunology
ER -
