The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk?

Karen M Garcia-Rodriguez; Anu Goenka; Maria T Alonso-Rasgado; Rogelio Hernández-Pando; Silvia Bulfone-Paus

doi:10.3389/fimmu.2017.01290

The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk?

Karen M Garcia-Rodriguez
, Anu Goenka
, Maria T Alonso-Rasgado
, Rogelio Hernández-Pando
, Silvia Bulfone-Paus

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

21 Citations (Scopus)

Abstract

Tuberculosis causes more annual deaths globally than any other infectious disease. However, progress in developing novel vaccines, diagnostics, and therapies has been hampered by an incomplete understanding of the immune response to Mycobacterium tuberculosis (Mtb). While the role of many immune cells has been extensively explored, mast cells (MCs) have been relatively ignored. MCs are tissue resident cells involved in defense against bacterial infections playing an important role mediating immune cell crosstalk. This review discusses specific interactions between MCs and Mtb, their contribution to both immunity and disease pathogenesis, and explores their role in orchestrating other immune cells against infections.

Original language	English
Pages (from-to)	1290
Journal	Frontiers in Immunology
Volume	8
DOIs	https://doi.org/10.3389/fimmu.2017.01290
Publication status	Published - 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.3389/fimmu.2017.01290

Handle.net

Persistent link

Cite this

@article{9e2937910b4a45149f512cab6029abc6,

title = "The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk?",

abstract = "Tuberculosis causes more annual deaths globally than any other infectious disease. However, progress in developing novel vaccines, diagnostics, and therapies has been hampered by an incomplete understanding of the immune response to Mycobacterium tuberculosis (Mtb). While the role of many immune cells has been extensively explored, mast cells (MCs) have been relatively ignored. MCs are tissue resident cells involved in defense against bacterial infections playing an important role mediating immune cell crosstalk. This review discusses specific interactions between MCs and Mtb, their contribution to both immunity and disease pathogenesis, and explores their role in orchestrating other immune cells against infections.",

author = "Garcia-Rodriguez, \{Karen M\} and Anu Goenka and Alonso-Rasgado, \{Maria T\} and Rogelio Hern{\'a}ndez-Pando and Silvia Bulfone-Paus",

year = "2017",

doi = "10.3389/fimmu.2017.01290",

language = "English",

volume = "8",

pages = "1290",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - The Role of Mast Cells in Tuberculosis

T2 - Orchestrating Innate Immune Crosstalk?

AU - Garcia-Rodriguez, Karen M

AU - Goenka, Anu

AU - Alonso-Rasgado, Maria T

AU - Hernández-Pando, Rogelio

AU - Bulfone-Paus, Silvia

PY - 2017

Y1 - 2017

N2 - Tuberculosis causes more annual deaths globally than any other infectious disease. However, progress in developing novel vaccines, diagnostics, and therapies has been hampered by an incomplete understanding of the immune response to Mycobacterium tuberculosis (Mtb). While the role of many immune cells has been extensively explored, mast cells (MCs) have been relatively ignored. MCs are tissue resident cells involved in defense against bacterial infections playing an important role mediating immune cell crosstalk. This review discusses specific interactions between MCs and Mtb, their contribution to both immunity and disease pathogenesis, and explores their role in orchestrating other immune cells against infections.

AB - Tuberculosis causes more annual deaths globally than any other infectious disease. However, progress in developing novel vaccines, diagnostics, and therapies has been hampered by an incomplete understanding of the immune response to Mycobacterium tuberculosis (Mtb). While the role of many immune cells has been extensively explored, mast cells (MCs) have been relatively ignored. MCs are tissue resident cells involved in defense against bacterial infections playing an important role mediating immune cell crosstalk. This review discusses specific interactions between MCs and Mtb, their contribution to both immunity and disease pathogenesis, and explores their role in orchestrating other immune cells against infections.

U2 - 10.3389/fimmu.2017.01290

DO - 10.3389/fimmu.2017.01290

M3 - Review article (Academic Journal)

C2 - 29089945

SN - 1664-3224

VL - 8

SP - 1290

JO - Frontiers in Immunology

JF - Frontiers in Immunology

ER -

The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk?

Abstract

UN SDGs

Access to Document

Handle.net

Fingerprint

Cite this