Projects per year
Neuronal calcium sensors (NCS) readily bind calcium and undergo conformational changes enabling them to interact and regulate specific target molecules. These interactions lead to dynamic alterations in protein trafficking that significantly impact upon synaptic function. Emerging evidence suggests that NCS and alterations in Ca(2+) mobilization modulate glutamate receptor trafficking, subsequently determining the expression of different forms of synaptic plasticity. In this review, we aim to discuss the functional relevance of NCS in protein trafficking and their emerging role in synaptic plasticity. Their significance within the concept of "translational neuroscience" will also be highlighted, by assessing their potential as key molecules in neurodegeneration.
|Translated title of the contribution||The role of neuronal calcium sensors in balancing synaptic plasticity and synaptic dysfunction|
|Pages (from-to)||57 - 57|
|Number of pages||1|
|Journal||Frontiers in Molecular Neuroscience|
|Publication status||Published - May 2012|
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- 1 Finished
THE EFFECTS OF ACUTE STRESS ON GLUTAMATE RECEPTOR TRAFFICKING AND SYNAPTIC PLASTICITY IN THE HIPPOCAMPUS
4/01/12 → 4/01/15