The role of procalcitonin in the management of pleural infection

Duneesha De Fonseka*, Nick A. Maskell

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

4 Citations (Scopus)
367 Downloads (Pure)


Purpose of review Pleural infection is a common problem associated with significant morbidity and mortality. Systemic or pleural fluid markers for reliably identifying pleural infection are limited. Procalcitonin (PCT) is known to be elevated in bacterial infection and is currently used for diagnosis and decision-making regarding antibiotic duration in respiratory infections. This review investigates if there is a role for serum and pleural fluid PCT (pf-PCT) in diagnosis and management of pleural infection. Recent findings Studies investigating the role of PCT have been limited by small patient numbers and heterogenous control populations. Overall, serum PCT (s-PCT) does not have a role superior to that of C-reactive protein (CRP) or leucocyte count (LCC) in diagnosing pleural infection or monitoring response to treatment. Similarly, pf-PCT demonstrated low sensitivity and specificity for diagnosing pleural infection. There was no role for PCT in determining which patients would require surgery as opposed to tube drainage alone. Summary There is currently insufficient evidence to recommend routine use of PCT for diagnosis and monitoring of pleural infection.

Original languageEnglish
Pages (from-to)380-383
Number of pages4
JournalCurrent Opinion in Pulmonary Medicine
Issue number4
Publication statusPublished - 1 Jul 2018


  • empyema
  • pleural infection
  • procalcitonin


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