The role of transmembrane sodium gradient in rabbit ileal smooth muscle: utilization of harmaline

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Abstract

Decreasing extracellular sodium concentration was found to produce a contractile response of rabbit ileal smooth muscle. As the concentration decreases, the amplitude of contraction increases, thus producing a dose-dependent curve. Harmaline, a competitor for sodium, was found to inhibit the sodium gradient-dependent contractions in a dose-dependent manner. The results are interpreted as harmaline inhibiting a Na-Ca exchange mechanism present in ileal smooth muscle.

Original languageEnglish
Pages (from-to)667-71
Number of pages5
JournalBioscience Reports
Volume5
Issue number8
Publication statusPublished - Aug 1985

Keywords

  • Alkaloids
  • Animals
  • Harmaline
  • Ileum
  • Kinetics
  • Membrane Potentials
  • Muscle Contraction
  • Muscle, Smooth
  • Rabbits
  • Sodium
  • Journal Article

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