Abstract
Decreasing extracellular sodium concentration was found to produce a contractile response of rabbit ileal smooth muscle. As the concentration decreases, the amplitude of contraction increases, thus producing a dose-dependent curve. Harmaline, a competitor for sodium, was found to inhibit the sodium gradient-dependent contractions in a dose-dependent manner. The results are interpreted as harmaline inhibiting a Na-Ca exchange mechanism present in ileal smooth muscle.
| Original language | English |
|---|---|
| Pages (from-to) | 667-71 |
| Number of pages | 5 |
| Journal | Bioscience Reports |
| Volume | 5 |
| Issue number | 8 |
| Publication status | Published - Aug 1985 |
Keywords
- Alkaloids
- Animals
- Harmaline
- Ileum
- Kinetics
- Membrane Potentials
- Muscle Contraction
- Muscle, Smooth
- Rabbits
- Sodium
- Journal Article