The SARS-CoV-2 spike protein: balancing stability and infectivity

Imre Berger; Christiane Schaffitzel

doi:10.1038/s41422-020-00430-4

The SARS-CoV-2 spike protein: balancing stability and infectivity

Imre Berger, Christiane Schaffitzel

Research output: Contribution to journal › Article (Academic Journal) › peer-review

69 Citations (Scopus)

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Abstract

SARS-CoV-2 spike (S) glycoprotein is the key target of current vaccine development efforts to combat COVID-19; neutralizing antibodies bind S and interfere with S binding to its receptor, angiotensin-converting enzyme 2. Recent work reveals the molecular basis of increased infectivity of the globally prevailing D614G S mutation.

Original language	English
Number of pages	2
Journal	Cell Research
Volume	2020
DOIs	https://doi.org/10.1038/s41422-020-00430-4
Publication status	Published - 2 Nov 2020

Research Groups and Themes

Bristol BioDesign Institute
Covid19

Keywords

cryoelectron microscopy
cryoelectron tomography

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41422-020-00430-4

Full-text PDF (author’s accepted manuscript)
This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Nature Research at https://www.nature.com/articles/s41422-020-00430-4 . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 287 KB

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Membrane protein insertion and quality control by the bacterial holo-translocon and FtsH chaperone/protease complex
Berger-Schaffitzel, C. H. (Principal Investigator)
9/01/17 → 8/07/20
Project: Research

Cite this

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abstract = "SARS-CoV-2 spike (S) glycoprotein is the key target of current vaccine development efforts to combat COVID-19; neutralizing antibodies bind S and interfere with S binding to its receptor, angiotensin-converting enzyme 2. Recent work reveals the molecular basis of increased infectivity of the globally prevailing D614G S mutation.",

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AB - SARS-CoV-2 spike (S) glycoprotein is the key target of current vaccine development efforts to combat COVID-19; neutralizing antibodies bind S and interfere with S binding to its receptor, angiotensin-converting enzyme 2. Recent work reveals the molecular basis of increased infectivity of the globally prevailing D614G S mutation.

KW - cryoelectron microscopy

KW - cryoelectron tomography

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The SARS-CoV-2 spike protein: balancing stability and infectivity

Abstract

Research Groups and Themes

Keywords

UN SDGs

Access to Document

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Projects

Membrane protein insertion and quality control by the bacterial holo-translocon and FtsH chaperone/protease complex

Cite this