The SARS-CoV-2 spike protein: balancing stability and infectivity

Research output: Contribution to journalArticle (Academic Journal)peer-review


SARS-CoV-2 spike (S) glycoprotein is the key target of current vaccine development efforts to combat COVID-19; neutralizing antibodies bind S and interfere with S binding to its receptor, angiotensin-converting enzyme 2. Recent work reveals the molecular basis of increased infectivity of the globally prevailing D614G S mutation.
Original languageEnglish
Number of pages2
JournalCell Research
Publication statusPublished - 2 Nov 2020

Structured keywords

  • Bristol BioDesign Institute


  • cryoelectron microscopy
  • cryoelectron tomography

Fingerprint Dive into the research topics of 'The SARS-CoV-2 spike protein: balancing stability and infectivity'. Together they form a unique fingerprint.

Cite this