The SARS-CoV-2 spike protein: balancing stability and infectivity

Imre Berger; Christiane Schaffitzel

doi:10.1038/s41422-020-00430-4

The SARS-CoV-2 spike protein: balancing stability and infectivity

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

SARS-CoV-2 spike (S) glycoprotein is the key target of current vaccine development efforts to combat COVID-19; neutralizing antibodies bind S and interfere with S binding to its receptor, angiotensin-converting enzyme 2. Recent work reveals the molecular basis of increased infectivity of the globally prevailing D614G S mutation.

Original language	English
Number of pages	2
Journal	Cell Research
Volume	2020
DOIs	https://doi.org/10.1038/s41422-020-00430-4
Publication status	Published - 2 Nov 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Groups and Themes

Bristol BioDesign Institute
Covid19

Keywords

cryoelectron tomography
cryoelectron microscopy
synthetic biology

Access to Document

10.1038/s41422-020-00430-4

Full-text PDF (author’s accepted manuscript)
This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Nature Research at https://www.nature.com/articles/s41422-020-00430-4 . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 287 KB

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Membrane protein insertion and quality control by the bacterial holo-translocon and FtsH chaperone/protease complex
Berger-Schaffitzel, C. H. (Principal Investigator)
9/01/17 → 8/07/20
Project: Research

Cite this

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abstract = "SARS-CoV-2 spike (S) glycoprotein is the key target of current vaccine development efforts to combat COVID-19; neutralizing antibodies bind S and interfere with S binding to its receptor, angiotensin-converting enzyme 2. Recent work reveals the molecular basis of increased infectivity of the globally prevailing D614G S mutation.",

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AB - SARS-CoV-2 spike (S) glycoprotein is the key target of current vaccine development efforts to combat COVID-19; neutralizing antibodies bind S and interfere with S binding to its receptor, angiotensin-converting enzyme 2. Recent work reveals the molecular basis of increased infectivity of the globally prevailing D614G S mutation.

KW - cryoelectron tomography

KW - cryoelectron microscopy

KW - synthetic biology

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JO - Cell Research

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The SARS-CoV-2 spike protein: balancing stability and infectivity

Abstract

UN SDGs

Research Groups and Themes

Keywords

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Projects

Membrane protein insertion and quality control by the bacterial holo-translocon and FtsH chaperone/protease complex

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