The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project

Christopher Medway*, Onofre Combarros, Mario Cortina-Borja, Helen T. Butler, Carla A. Ibrahim-Verbaas, Renee F. A. G. de Bruijn, Peter J. Koudstaal, Cornelia M. van Duijn, M. Arfan Ikram, Ignacio Mateo, Pascual Sanchez-Juan, Michael G. Lehmann, Reinhard Heun, Heike Koelsch, Panos Deloukas, Naomi Hammond, Eliecer Coto, Victoria Alvarez, Patrick G. Kehoe, Rachel BarberGordon K. Wilcock, Kristelle Brown, Olivia Belbin, Donald R. Warden, A. David Smith, Kevin Morgan, Donald J. Lehmann

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

30 Citations (Scopus)

Abstract

Epistasis between interleukin-10 (IL10) and aromatase gene polymorphisms has previously been reported to modify the risk of Alzheimer's disease (AD). However, although the main effects of aromatase variants suggest a sex-specific effect in AD, there has been insufficient power to detect sex-specific epistasis between these genes to date. Here we used the cohort of 1757 AD patients and 6294 controls in the Epistasis Project. We replicated the previously reported main effects of aromatase polymorphisms in AD risk in women, for example, adjusted odds ratio of disease for rs1065778 GG=1.22 (95% confidence interval: 1.01-1.48, P=0.03). We also confirmed a reported epistatic interaction between IL10 rs1800896 and aromatase (CYP19A1) rs1062033, again only in women: adjusted synergy factor=1.94 (1.16-3.25, 0.01). Aromatase, a rate-limiting enzyme in the synthesis of estrogens, is expressed in AD-relevant brain regions ,and is downregulated during the disease. IL-10 is an anti-inflammatory cytokine. Given that estrogens have neuroprotective and anti-inflammatory activities and regulate microglial cytokine production, epistasis is biologically plausible. Diminishing serum estrogen in postmenopausal women, coupled with suboptimal brain estrogen synthesis, may contribute to the inflammatory state, that is a pathological hallmark of AD.European Journal of Human Genetics advance online publication, 5 June 2013; doi:10.1038/ejhg.2013.116.
Original languageEnglish
Pages (from-to)216-220
Number of pages5
JournalEuropean Journal of Human Genetics
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • healthy cell bias
  • C18
  • dementia
  • neurodegeneration
  • BREAST-CANCER RISK
  • ESTROGEN-RECEPTOR
  • POSTMENOPAUSAL WOMEN
  • CYP19 AROMATASE
  • BLOOD-PRESSURE
  • NEUROPROTECTIVE ACTIONS
  • PROMOTER POLYMORPHISM
  • CLINICAL-IMPLICATIONS
  • INTERLEUKIN-10 GENE
  • GENDER-DIFFERENCES

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