The significance of glucocorticoid pulsatility

SL Lightman, CCR Wiles, HC Atkinson, DE Henley, GM Russell, JA Leendertz, MA McKenna, F Spiga, SA Wood, BL Conway-Campbell

Research output: Contribution to journalReview article (Academic Journal)peer-review

155 Citations (Scopus)


Glucocorticoids are secreted in discrete pulses resulting in an ultradian rhythm in all species that have been studied. In the rat there is an approximately hourly rhythm of corticosterone secretion, which appears to be regulated by alternating activation and inhibition of the HPA axis. At the level of signal transduction, the response to these pulses of corticosterone is determined by its dynamic interaction with the two transcription factors--the glucocorticoid and mineralocorticoid receptors. While the mineralocorticoid receptor remains activated throughout the ultradian cycle, the glucocorticoid receptor shows a phasic response to each individual pulse of corticosterone. This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor.
Translated title of the contributionThe significance of glucocorticoid pulsatility
Original languageEnglish
Pages (from-to)255 - 262
Number of pages8
JournalEuropean Journal of Pharmacology
Publication statusPublished - Apr 2008

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